DC 4: Hit discovery and structural studies of riboswitch-ligand complexes using NMR and X-ray crystallography

PhD project description:

This PhD project will focus on using NMR spectroscopy for the characterization of the structure and dynamics of two riboswitches in complex with small molecule ligands. Further, different biophysical screening modalities will be compared for the identification of fragment hits for RNA targets. The PhD student will work in an interdisciplinary environment where NMR spectroscopy is used to address structural, dynamic, and metabolomic data from different sources such as chemical, biochemical, or other natural systems. You will have opportunities to work with other scientists within and outside the TargetRNA  doctoral network and to collaborate with and supervise undergraduate students.

Research environment:

The laboratory of Assoc. Prof. Charlotte H. Gotfredsen focuses on NMR spectroscopy for multiple uses in chemical biology and biological chemistry. The group carries out projects where NMR spectroscopy is used as the main analytical technique within RNA structure determination, secondary metabolite structure determination and in situ metabolomic studies as well as NMR based FBDD screening. Furthermore, we work with new developments within NMR spectroscopy both software for metabolomic data deconvolution and alignment media enabling the extraction of long-range NMR structural parameters.
You can read more about DTU Chemistry at www.kemi.dtu.dk/english and more about the CHG group and the NMR Center DTU at www.kemi.dtu.dk/chg

Skills/qualifications:

• 5-years degree (Master) in Organic/Medicinal Chemistry, or related fields.
• Practical experience in organic chemistry and biophysical techniques.
• Good level of English proficiency (understood, spoken and written).
• Team spirit and proactive attitude.

Benefits/salary/social security:

The salary for this position will be DKK 428.493 (€ 57.516).
The period of employment is 36 months. Starting date is January 2025-April 2025 (or according to mutual agreement). The position is a full-time position.

The salary includes pension and the appointment will be based on collective agreement between the Danish State and the Danish Confederation of Professional Associations, and the allowance will be agreed upon with the relevant union. Denmark has public health care for all, and work insurance is covered while employed by DTU.

The Technical University of Denmark (DTU) is located in the greater Copenhagen area, which is acknowledged for its excellent standards of living, childcare and welfare system.

For more information about the position, please contact Charlotte H. Gotfredsen.