Bjørn Tore Gjertsen, MD, PhD. is Professor of Hematology from 2007 at Department of Clinical Science at the University of Bergen, working as Research Chief and Consultant Hematologist at Helse Bergen Health Trust, developing early phase clinical trials at Haukeland University Hospital. In 2016 Gjertsen was appointed co-director for Centre for Cancer Biomarkers (CCBIO) Norwegian Centre of Excellence, University of Bergen. His major research interest is development of targeted therapy and accompanying diagnostics in the aggressive blood cancer acute myeloid leukemia. His laboratory is working on intracellular signal transduction and its regulation of the tumor suppressor protein p53. Single cell signaling and immune profiling by multiplexing mass cytometry has been developed for monitoring of immuno- and signaling-directed therapy and is currently used for therapy development of various cancers and myeloid leukemias.

2025

• Gullaksen, Stein-Erik; Omsland, Maria; Brevik, Mathias et al. (2025). CML stem cells and their interactions and adaptations to tyrosine kinase inhibitors. (ekstern lenke)

2024

• Flygt, Hjalmar; Söderlund, Stina; Richter, Johan et al. (2024). Correction to: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial (Leukemia, (2024), 10.1038/s41375-024-02145-6). (ekstern lenke)
• Hemminki, Kari; Zitricky, Frantisek; Försti, Asta et al. (2024). Age-specific survival in acute myeloid leukemia in the Nordic countries through a half century. (ekstern lenke)
• Cuminetti, Vincent; Konieczny, Joanna; Bernal Mera, Aurora et al. (2024). Succinate receptor 1 signaling regulates hematopoiesis via S100/a8 and S100/a9 in health and malignancy. (ekstern lenke)
• Helland, Åslaug; Steinskog, Eli Sihn Samdal; Blix, Egil Støre et al. (2024). Hever kvaliteten på behandling av kreft. (ekstern lenke)
• Kleftogiannis, Dimitrios; Gavasso, Sonia; Tislevoll, Benedicte Sjo et al. (2024). Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry. (ekstern lenke)
• Sefland, Øystein; Gullaksen, Stein-Erik; Omsland, Maria et al. (2024). Mass cytometric single cell immune profiles of peripheral blood from acute myeloid leukemia patients in complete remission with measurable residual disease. (ekstern lenke)
• Venanzi, Alessandra; Cardinali, Valeria; Perriello, Vincenzo et al. (2024). Starry sky pattern predicts RAS pathway activation in NPM1-mutated acute myeloid leukemia. (ekstern lenke)
• Caulier, Benjamin William; Joaquina, Sandy; Gelebart, Pascal Francois et al. (2024). CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia. (ekstern lenke)
• Khan, Alesia A.; James, Daniel; Andresen, Vibeke et al. (2024). Pre-B acute lymphoblastic leukemia presenting with NPM1 and FLT3 mutations. (ekstern lenke)
• Eldfors, Samuli; Saad, Joseph; Ikonen, Nemo et al. (2024). Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia. (ekstern lenke)
• Lygre, Kristin Bentung; Forthun, Rakel Brendsdal; Høysæter, Trude et al. (2024). Assessment of postoperative circulating tumour DNA to predict early recurrence in patients with stage I–III right-sided colon cancer: prospective observational study. (ekstern lenke)
• Flygt, Hjalmar; Söderlund, Stina; Richter, Johan et al. (2024). Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial. (ekstern lenke)
• Ha, Trung Quang; Andresen, Vibeke; Erikstein, Bjarte Skoe et al. (2024). Preclinical activity of resazurin in acute myeloid leukaemia. (ekstern lenke)

2023

• Tettero, Jesse M.; Buisman, Yara; Ngai, Lok Lam et al. (2023). Prognostic Significance of Measurable Residual Disease Detection by Flow Cytometry in Autologous Stem Cell Apheresis Products in AML. (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Gjertsen, Bjørn Tore et al. (2023). A prospective non-randomized phase I trial of dendritic cell–based cryoimmunotherapy combined with checkpoint inhibitors in mCRPC.. (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC). (ekstern lenke)
• Rosti, Gianantonio; Brümmendorf, Tim H.; Gjertsen, Bjørn Tore et al. (2023). Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study. (ekstern lenke)
• Tvedt Skarstein, Andreas; Hoang, Tuyen; Haugen, Hallvard et al. (2023). In vitro Study of STAT3-inhibitors in Drug-Resistant Chronic Myeloid Leukemia (CML). (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer. (ekstern lenke)
• Othman, Jad; Meggendorfer, Manja; Tiacci, Enrico et al. (2023). Overlapping features of therapy-related and de novo NPM1-mutated AML. (ekstern lenke)
• Ngai, Lok Lam; Hanekamp, Diana; Janssen, Fleur et al. (2023). Prospective validation of the prognostic relevance of CD34⁺CD38^– AML stem cell frequency in the HOVON-SAKK132 trial. (ekstern lenke)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia (Nature Communications, (2023), 14, 1, (115), 10.1038/s41467-022-35624-4). (ekstern lenke)
• Falini, Brunangelo; Gjertsen, Bjørn Tore; Andresen, Vibeke (2023). The acidic stretch and the C-terminal nuclear export signal motif of NPM1 mutant: are they druggable in AML?. (ekstern lenke)
• Falini, Brunangelo; Martelli, Maria Paola; Brunetti, Lorenzo et al. (2023). The NPM1 mutant defines AML irrespective of blast count. (ekstern lenke)
• Geelen, Inge G.P.; Gullaksen, Stein-Erik; Ilander, Mette M. et al. (2023). Switching from imatinib to nilotinib plus pegylated interferon-α2b in chronic phase CML failing to achieve deep molecular response: clinical and immunological effects. (ekstern lenke)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (ekstern lenke)
• Fløisand, Yngvar; Remberger, Mats; Bigalke, Iris et al. (2023). WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy. (ekstern lenke)
• Tettero, Jesse M.; Ngai, Lok Lam; Bachas, Costa et al. (2023). Measurable residual disease-guided therapy in intermediate-risk acute myeloid leukemia patients is a valuable strategy in reducing allogeneic transplantation without negatively affecting survival. (ekstern lenke)
• Hokland, Peter; Fernández, Isolda I.; Freeman, Sylvie D. et al. (2023). AML in the elderly—A global view. (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC) . (ekstern lenke)

2022

• Jenssen, Astrid Bjørke; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kankuri, Esko et al. (2022). Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds. (ekstern lenke)
• Tettero, Jesse M.; Al-Badri, Waleed K. W.; Ngai, Lok Lam et al. (2022). Concordance in measurable residual disease result after first and second induction cycle in acute myeloid leukemia: An outcome- and cost-analysis. (ekstern lenke)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2022). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (ekstern lenke)
• Kleftogiannis, Dimitrios; Tislevoll, Benedicte Sjo; Hellesøy, Monica et al. (2022). Identifying predictors of survival in patients with leukemia using single-cell mass cytometry and machine learning. (ekstern lenke)
• Pianigiani, Giulia; Rocchio, Francesca; Peruzzi, Sara et al. (2022). The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein. (ekstern lenke)
• Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan et al. (2022). IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia. (ekstern lenke)
• Tasken, Kjetil; Russnes, Hege Elisabeth Giercksky; Aas, Eline et al. (2022). A national precision cancer medicine implementation initiative for Norway. (ekstern lenke)
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live et al. (2022). Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway (Journal of Translational Medicine, (2022), 20, 1, (225), 10.1186/s12967-022-03432-5). (ekstern lenke)
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live et al. (2022). Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. (ekstern lenke)

2021

• Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon et al. (2021). p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy. (ekstern lenke)
• Engen, Caroline ; Hellesøy, Monica; Grob, Tim et al. (2021). FLT3-ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation. (ekstern lenke)
• Flygt, Hjalmar; Söderlund, Stina; Stentoft, Jesper et al. (2021). Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP: Five-year follow-up of the NordCML007 study. (ekstern lenke)
• Sletta, Kristine Yttersian; Marin, Oriol Castells; Gjertsen, Bjørn Tore (2021). Colony stimulating factor 1 receptor in acute myeloid leukemia. (ekstern lenke)
• Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten et al. (2021). Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System . (ekstern lenke)
• Rana, Neha; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2021). Systemic and local innate immune responses to surgical co-transplantation of mesenchymal stromal cells and biphasic calcium phosphate for bone regeneration. (ekstern lenke)
• Malani, Disha; Adish Kumar, Kumar; Brück, Oscar et al. (2021). Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia. (ekstern lenke)
• Ngai, Lok Lam; Ma, Connie Y.; Maguire, Orla et al. (2021). Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients. (ekstern lenke)
• Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi et al. (2021). Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial. (ekstern lenke)
• Löwenberg, Bob; Pabst, Thomas; Maertens, Johan et al. (2021). Addition of lenalidomide to intensive treatment in younger and middle-aged adults with newly diagnosed AML: The HOVON-SAKK-132 trial. (ekstern lenke)
• Janssen, Jeroen; Löwenberg, Bob; Manz, Markus et al. (2021). Inferior outcome of addition of the aminopeptidase inhibitor tosedostat to standard intensive treatment for elderly patients with aml and high risk mds. (ekstern lenke)
• Bakunina, Katerina; Putter, Hein; Versluis, Jurjen et al. (2021). The added value of multi-state modelling in a randomized controlled trial: The HOVON 102 study re-analyzed. (ekstern lenke)
• Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes et al. (2021). Thrombosis and thrombocytopenia after HPV vaccination. (ekstern lenke)
• Gundersen, Edvin Tang; Førde, Jan-Lukas; Tislevoll, Benedicte Sjo et al. (2021). Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation. (ekstern lenke)
• Jaffredo, Thierry; Balduini, Alessandra; Bigas, Anna et al. (2021). The eha research roadmap: normal hematopoiesis. (ekstern lenke)
• Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim et al. (2021). Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis. (ekstern lenke)
• Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu et al. (2021). Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions. (ekstern lenke)
• Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik et al. (2021). Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods. (ekstern lenke)
• Mosleth, Ellen Færgestad; Vedeler, Christian Alexander; Liland, Kristian Hovde et al. (2021). Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis. (ekstern lenke)
• Rana, Neha; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2021). Systemic monocyte-macrophage response to co-transplanting mesenchymal stromal cells and biphasic calcium phosphate biomaterial for bone regeneration. (ekstern lenke)
• Shafiee, Sahba; Gelebart, Pascal Francois; Popa, Mihaela-Lucia et al. (2021). Preclinical characterisation and development of a novel myelodysplastic syndrome-derived cell line. (ekstern lenke)

2020

• Ossenkoppele, G.J.; Breems, D.A.; Stuessi, G. et al. (2020). Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS (Leukemia, (2020), 34, 7, (1751-1759), 10.1038/s41375-020-0725-0). (ekstern lenke)
• Ossenkoppele, G.J.; Breems, D.A.; Stuessi, G. et al. (2020). Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS. (ekstern lenke)
• Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik et al. (2020). Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines (. (ekstern lenke)
• Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari et al. (2020). CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. (ekstern lenke)
• Engen, Caroline Benedicte Nitter; Gjertsen, Bjørn Tore; Bruserud, Øystein et al. (2020). Exploring the boundaries of precision haemato-oncology – The case of FLT3 length mutated acute myeloid leukaemia. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Murvold, Elisa Thodesen et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (ekstern lenke)
• Mercatelli, Daniele; Bortolotti, Massimo; Andresen, Vibeke et al. (2020). Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling. (ekstern lenke)
• Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen et al. (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. (ekstern lenke)
• Alme, Eirin; Törnroos, Karl Wilhelm; Gjertsen, Bjørn Tore et al. (2020). Synthesis of N-aryl- and N-alkyl-substituted imidazolium silver complexes: Cytotoxic screening by using human cell lines modelling acute myeloid leukaemia. (ekstern lenke)
• Hochhaus, Andreas; Gambacorti-Passerini, Carlo; Abboud, Camille et al. (2020). Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study. (ekstern lenke)
• Majumder, Muntasir M.; Leppä, Aino-Maija; Hellesøy, Monica et al. (2020). Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types. (ekstern lenke)
• Tadele, Dagim Shiferaw; Robertson, Joseph; Crispin, Richard et al. (2020). A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation. (ekstern lenke)
• Bjørsvik, Hans-René; Gjertsen, Bjørn Tore; Elumalai, Vijayaragavan (2020). Hit to leads with cytotoxic effect in leukemic cells: Total synthesis intermediates as a molecule treasure chest. (ekstern lenke)
• Kuusanmäki, Heikki; Leppä, Aino-Maija; Pölönen, Petri et al. (2020). Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia. (ekstern lenke)
• Tambe, Mahesh; Karjalainen, Ella; Vähä-Koskela, Markus et al. (2020). Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition. (ekstern lenke)
• Onyango, Therese Bredholt; Hjelle, Sigrun Margrethe; Haaland, Ingvild et al. (2020). A comparison of p53 isoform profiles and apoptosis induced by camptothecin or a herbal khat extract (Catha edulis (vahl) forssk. ex endl.) in leukemic cell lines: Exploring cellular responses in therapy development. (ekstern lenke)
• Wang, Xiang; Deng, Linhong; Gjertsen, Bjørn Tore (2020). A microfluidic device for differential capture of heterogeneous rare tumor cells with epithelial and mesenchymal phenotypes. (ekstern lenke)
• Fagerholt, Oda Helen Eck; Hellesøy, Monica; Gullaksen, Stein-Erik et al. (2020). Single cell detection of the p53 protein by mass cytometry. (ekstern lenke)

2019

• Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre et al. (2019). Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia. (ekstern lenke)
• Bischof, Katharina; Bjørge, Line; Gjertsen, Bjørn Tore et al. (2019). Rethinking Gynecological High- Grade Serous Carcinoma. Portraying the p53 isoform landscape and development of a new preclinical for optical imaging in xenograft models. (ekstern lenke)
• Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica et al. (2019). Titrating complex mass cytometry panels. (ekstern lenke)
• Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe et al. (2019). Influence of p53 isoform expression on survival in high-grade serous ovarian cancers. (ekstern lenke)
• Kreutzman, Anna; Yadav, Bhagwan; Brümmendorf, Tim H. et al. (2019). Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik et al. (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. (ekstern lenke)
• Zhang, Beibei; Ayuda-Duran, Maria del Pilar; Piechaczyk, Laure Isabelle et al. (2019). GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells. (ekstern lenke)
• Andresen, Vibeke; Gjertsen, Bjørn Tore (2019). Clinical trials of repurposing medicines in acute myeloid leukemia: Limitations and possibilities in the age of precision therapy. (ekstern lenke)
• Jebsen, Nina Louise; Apelseth, Torunn Oveland; Haugland, Hans Kristian et al. (2019). Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: A case report. (ekstern lenke)
• Gras Navarro, Andrea; Espedal, Heidi; Vareecal Joseph, Justin et al. (2019). Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival. (ekstern lenke)
• Lundevall, Frida Johanne; Bedringaas, Siv Lise; Törnroos, Karl Wilhelm et al. (2019). Synthesis and investigation of Ag-NHC complexes with cytotoxic properties towards cell lines modelling acute myeloid leukemia . (ekstern lenke)
• Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore et al. (2019). Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.. (ekstern lenke)
• Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia et al. (2019). ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab. (ekstern lenke)
• Rahman, Mohummad Aminur; Gras Navarro, Andrea; Brekke, Jorunn et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (ekstern lenke)
• Gjertsen, Bjørn Tore; Tislevoll, Benedicte Sjo; Fagerholt, Oda Helen Eck et al. (2019). Early response evaluation in AML using mass cytometry. (ekstern lenke)

2018

• Jørgensen, Katarina Mariann; Mosleth, Ellen Færgestad; Liland, Kristian Hovde et al. (2018). Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels. (ekstern lenke)
• Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik et al. (2018). Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. (ekstern lenke)
• Schuster, Cornelia; Gausdal, Gro; Gjertsen, Bjørn Tore et al. (2018). Update on the randomised phase Ib/II study of the selective small molecule AXL inhibitor bemcentinib (BGB324) in combination with either dabrafenib/trametinib or pembrolizumab in patients with metastatic melanoma. (ekstern lenke)
• Bischof, Katharina; Knappskog, Stian; Stefansson, Ingunn et al. (2018). High expression of the p53 isoform ? is associated with reduced progression-free survival in uterine serous carcinoma. (ekstern lenke)
• Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Hellem, Sølve et al. (2018). Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. . (ekstern lenke)
• Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise et al. (2018). Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. (ekstern lenke)
• Kirkeleit, Jorunn; Riise, Trond; Bjørge, Tone et al. (2018). Maternal exposure to gasoline and exhaust increases the risk of childhood leukaemia in offspring - a prospective study in the Norwegian Mother and Child Cohort Study. (ekstern lenke)
• Brattås, Marte Karen; Lilleeng, Kyrre Flattun; Hovland, Randi et al. (2018). Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis. (ekstern lenke)
• Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi et al. (2018). Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia. (ekstern lenke)
• Omsland, Maria; Pise-Masison, Cynthia A.; Fujikawa, Dai et al. (2018). Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine. (ekstern lenke)
• Gullaksen, Stein-Erik; Gjertsen, Bjørn Tore; Kirkeleit, Jorunn et al. (2018). Single cell signalling and immune profiles in chronic myeloid leukaemia . (ekstern lenke)

2017

• Forthun, Rakel Brendsdal; Sulen, Andre; Sjøholt, Gry et al. (2017). combination of interferon-alpha and valproic acid in acute myeloid leukemia cells in vitro and in vivo. (ekstern lenke)
• Sopper, Sieghart; Mustjoki, Satu; Gjertsen, Bjørn Tore et al. (2017). NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib. (ekstern lenke)
• Sabir, Misbah; Hellesøy, Monica; Kivioja, Jarno et al. (2017). development of novel Highly Specific FLT3 Targeted Inhibitors for Combination or Sequential Therapy of Acute Myeloid Leukemia. (ekstern lenke)
• Karjalainen, Riikka; Popa, Mihaela Lucia; Liu, M et al. (2017). Stroma-derived factors stimulate JAK/STAT signaling in AML cells resulring in resistance to BCL2 inhibitor Venetoclax. (ekstern lenke)
• Ayuda-Duran, Maria del Pilar; Zhang, B; Piechaczyck, L. et al. (2017). a precision medicin platform for acute myeloid leukemia to help unraveling the molecular addictions of FLT3-ITD-driven AML. (ekstern lenke)
• Kotopoulis, Spiros; Stigen, Endre; Popa, Mihaela Lucia et al. (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. (ekstern lenke)
• Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia et al. (2017). Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. (ekstern lenke)
• Reikvam, Håkon; Hovland, Randi; Forthun, Rakel Brendsdal et al. (2017). Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells. (ekstern lenke)
• Karjalainen, Riikka; Pemovska, Tea; Popa, Mihaela Lucia et al. (2017). JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML. (ekstern lenke)
• Omsland, Maria; Bruserud, Øystein; Gjertsen, Bjørn Tore et al. (2017). Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-KB inhibition in acute myeloid leukemia (AML). (ekstern lenke)
• Rajala, Hanna L.M.; El Missiry, Mohamed; Ruusila, Anniina et al. (2017). Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia. (ekstern lenke)
• Gjertsen, Bjørn Tore (2017). Proteomics and single cell immune and signaling profiling of myeloid leukemia. (ekstern lenke)
• Kontro, Mika; Kumar, Anil; Majumder, Muntasir Mamun et al. (2017). HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia. (ekstern lenke)
• Andresen, Vibeke; Gjertsen, Bjørn Tore (2017). Drug Repurposing for the Treatment of Acute Myeloid Leukemia. (ekstern lenke)
• Laukkanen, S; Grönroos, T; Pölönen, P et al. (2017). In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL. (ekstern lenke)
• Lowenberg, Bob; Pabst, Thomas; Maertens, Johan et al. (2017). Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML. (ekstern lenke)
• Jebsen, Nina Louise; Scarlett, Samantha; Magnusdottir, Bergrun Tinna et al. (2017). Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy. (ekstern lenke)
• Forthun, Rakel Brendsdal; Aasebø, Elise; Rasinger, Josef Daiel et al. (2017). Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia. (ekstern lenke)
• Sopper, Sieghart; Mustjoki, Satu; White, Deborah et al. (2017). Reduced CD62L expression on T cells and increased soluble CD62L levels predict molecular response to tyrosine kinase inhibitor therapy in early chronic-phase chronic myelogenous leukemia. (ekstern lenke)

2016

• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. (ekstern lenke)
• Hjorth-Hansen, Henrik; Stentoft, Jesper; Richter, Johan et al. (2016). Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients. (ekstern lenke)
• Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius et al. (2016). Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. (ekstern lenke)
• Sulen, Andre; Gjertsen, Bjørn Tore (2016). Leukocyte p38 and p53 proteins after environmental exposure; variation, associations and applicability. (ekstern lenke)
• Thielen, Noortje; Richter, Johan; Baldauf, Matthias et al. (2016). Leukemic stem cell quantification in newly diagnosed patients with chronic myeloid leukemia predicts response to nilotinib therapy. (ekstern lenke)
• Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina et al. (2016). The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer. (ekstern lenke)
• Engen, Caroline Benedicte Nitter; Hajjar, Ehsan; Gjertsen, Bjørn Tore (2016). Development of personalized molecular therapy for acute myeloid leukemia. (ekstern lenke)
• Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel et al. (2016). Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Mc Cormack, Emmet et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; McCormack, Emmet et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. (ekstern lenke)
• Gavasso, Sonia; Gullaksen, Stein-Erik; Skavland, Jørn et al. (2016). Single-cell proteomics: Potential implications for cancer diagnostics. (ekstern lenke)
• Leitch, Calum; Osdal, Tereza; Andresen, Vibeke et al. (2016). Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. (ekstern lenke)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. (ekstern lenke)
• Sulen, Andre; Lygre, Stein Håkon Låstad; Hjelle, Sigrun Margrethe et al. (2016). Elevated monocyte phosphorylated p38 in nearby employees after a chemical explosion. (ekstern lenke)

2015

• Sandtorv, Alexander Harald; Leitch, Calum; Bedringaas, Siv Lise et al. (2015). 4-alkylated silver-N-heterocyclic carbene (NHC) complexes with cytotoxic effects in leukemia cells. (ekstern lenke)
• Myklebost, Ola; Lothe, Ragnhild A; Gjertsen, Bjørn Tore et al. (2015). Bør hver kreftpasient bli et eget forskningsprosjekt?. (ekstern lenke)
• Bruserud, Øystein; Reikvam, Håkon; Fredly, Hanne Kristin et al. (2015). Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. (ekstern lenke)
• Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin et al. (2015). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. (ekstern lenke)
• Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin et al. (2015). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. (ekstern lenke)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (ekstern lenke)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (ekstern lenke)
• Gjertsen, Bjørn Tore; Schöffski, Patrick (2015). Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy. (ekstern lenke)
• Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina et al. (2015). Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006). (ekstern lenke)
• Mukherjee, Herschel; Chan, Kok-Ping; Andresen, Vibeke et al. (2015). Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 mediate the cellular localization of nucleophosmin and its aml-associated mutants. (ekstern lenke)

2014

• Engen, Caroline Benedicte Nitter; Wergeland, Line; Skavland, Jørn et al. (2014). Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela Lucia et al. (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gjertsen, Bjørn Tore et al. (2014). Sonoporation: from the lab to human clinical trials. (ekstern lenke)
• Kotopoulis, Spiros; Haugse, Ragnhild; Mujic, Maja et al. (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. (ekstern lenke)
• Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten et al. (2014). First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma. (ekstern lenke)
• Li, Ling; Osdal, Tereza; Ho, Yinway et al. (2014). SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. (ekstern lenke)
• Andresen, Vibeke; Omsland, Maria; Gjertsen, Bjørn Tore et al. (2014). Cell-to-Cell Communication in Acute Myeloid Leukemia by Tunneling Nanotubes. (ekstern lenke)
• Kontro, M; Kuusanmäki, H; Eldfors, S et al. (2014). Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia. (ekstern lenke)
• Hampson, Peter; Wang, Keqing; Ersvær, Elisabeth et al. (2014). Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukemic compound PEP005 in primary AML cells. (ekstern lenke)
• Aasebø, Elise; Vaudel, Marc; Mjaavatten, Olav et al. (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. (ekstern lenke)
• Gjertsen, Bjørn Tore (2014). Mot en mer spesifikk kreftbehandling? :. (ekstern lenke)
• Rizzieri, David A.; Vey, Norbert; Thomas, Xavier et al. (2014). A phase II study of elacytarabine in combination with idarubicin and of human equilibrative nucleoside transporter 1 expression in patients with acute myeloid leukemia and persistent blasts after the first induction course. (ekstern lenke)
• Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode et al. (2014). Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. (ekstern lenke)
• Gavasso, Sonia; Mosleth, Ellen Færgestad; Marøy, Tove Helene et al. (2014). Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta. (ekstern lenke)

2013

• Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe et al. (2013). Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. (ekstern lenke)
• Engen, Caroline Benedicte Nitter; Wergeland, Line; Gjertsen, Bjørn Tore (2013). Målrettet behandling av akutt myelogen leukemi - hemmere mot FLT3 og andre kinaser viser vei. (ekstern lenke)
• McCormack, Emmet ; Silden, Elisabeth; West, Richard M. et al. (2013). Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. (ekstern lenke)
• Silden, Elisabeth; Hjelle, Sigrun Margrethe; Wergeland, Line et al. (2013). Expression of TP53 isoforms p53 beta or p53 gamma enhances chemosensitivity in TP53(null) cell lines. (ekstern lenke)
• McCormack, Emmet ; Mujic, Maja; Osdal, Tereza et al. (2013). Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela et al. (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. (ekstern lenke)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Hoem, Dag et al. (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. (ekstern lenke)
• Mujic, Maja; Haugse, Ragnhild; Kotopoulis, Spiros et al. (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. (ekstern lenke)
• Helland, Øystein; Popa, Mihaela Lucia; Gjertsen, Bjørn Tore et al. (2013). Panobinostat / carboplatin delay postsurgical relapse of ovarian carcinomas in an orthotopic mouse model. (ekstern lenke)
• Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Bruserud, Øystein (2013). Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents. (ekstern lenke)
• Fredly, Hanne Kristin; Ersvær, Elisabeth; Kittang, Astrid Marta Olsnes et al. (2013). The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia. (ekstern lenke)
• Helland, Øystein; Bishof, Katharina; Popa, Mihaela Lucia et al. (2013). Histone deacetylase inhibisjon i kombinasjon med platinum i en klinisk relevant ortotopisk musemodel for ovarialcancer. (ekstern lenke)
• Helland, Øystein; Mihaela, P.; Gjertsen, Bjørn Tore et al. (2013). PANOBINOSTAT / CARBOPLATIN DELAY POSTSURGICAL RELAPSE OF OVARIAN CARCINOMA IN AN ORTHOTOPIC MOUSE MODEL. (ekstern lenke)
• Reikvam, Håkon; Kittang, Astrid Marta Olsnes; Melve, Guro Kristin et al. (2013). Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?. (ekstern lenke)
• Gausdal, Gro; Wergeland, Anita; Skavland, Jørn et al. (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. (ekstern lenke)
• Øye, Ola Kristoffer; Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe et al. (2013). Gel2DE-A software tool for correlation analysis of 2D gel electrophoresis data. (ekstern lenke)
• Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore et al. (2013). Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. (ekstern lenke)
• Andresen, Vibeke; Wang, Xiang; Ghimire, Sakhila et al. (2013). Tunneling nanotube (TNT) formation is independent of p53 expression. (ekstern lenke)
• Gjertsen, Bjørn Tore (2013). Phosphoprotein signaling in acute myeloid leukemia. (ekstern lenke)
• Pemovska, Tea; Kontro, Mika; Yadav, Bhagwan et al. (2013). Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. (ekstern lenke)
• Mustjoki, Satu; Richter, Johan; Barbany, Gisela et al. (2013). Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients. (ekstern lenke)
• Reikvam, Håkon; Nepstad, Ina; Sulen, Andre et al. (2013). Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors. (ekstern lenke)
• McCormack, Emmet ; Adams, Katherine J.; Hassan, Namir J. et al. (2013). Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1-and LAGE-1-positive tumors. (ekstern lenke)
• Kloster, Martine Müller; Naderi, Elin Hallan; Haaland, Ingvild et al. (2013). cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. (ekstern lenke)

2012

• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2012). Microbubbles and cell interactions. (ekstern lenke)
• Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth et al. (2012). Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. (ekstern lenke)
• McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid et al. (2012). Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. (ekstern lenke)
• Ånensen, Nina; Hjelle, Sigrun Margrethe; Van, Belle Werner et al. (2012). Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. (ekstern lenke)
• Hjelle, Sigrun Margrethe; Sulen, Andre; Øye, Ola Kristoffer et al. (2012). Leukocyte p53 protein biosignature through standard-aligned two-dimensional immunoblotting. (ekstern lenke)
• Oveland, Eystein; Wergeland, Line; Hovland, Randi et al. (2012). Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. (ekstern lenke)
• Mujic, Maja; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. (ekstern lenke)
• Fredly, Hanne Kristin; Reikvam, Håkon; Gjertsen, Bjørn Tore et al. (2012). Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment. (ekstern lenke)
• Gavasso, Sonia; Gjertsen, Bjørn Tore; Anderssen, Endre et al. (2012). Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis. (ekstern lenke)
• Giles, Francis; Mahon, François-Xavier; Gjertsen, Bjørn Tore et al. (2012). Developmental Therapeutics Consortium report on study design effects on trial outcomes in chronic myeloid leukaemia. (ekstern lenke)
• Gjertsen, Bjørn Tore; Wiig, Helge (2012). Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid. (ekstern lenke)
• Bjugn, Roger; Gjertsen, Bjørn Tore (2012). Human cells and the Norwegian Health Research Act. (ekstern lenke)
• Øye, Ola Kristoffer; Ulvang, Dag Magne; Jørgensen, Katarina Mariann et al. (2012). Volume visualization for exploration of population trends in two-dimensional gel electrophoresis protein data. (ekstern lenke)
• Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten et al. (2012). Establishment of a bioluminescence orthotopic mouse model of ovarian carcinoma: Analysis of tumor growth and response to therapy. (ekstern lenke)
• Rizzieri, David A.; Vey, Norbert; Thomas, Xavier et al. (2012). A Phase II Study of Elacytarabine/Idarubicin As Second Course Remission-Induction in Patients with Acute Myeloid Leukemia Who Failed Cytarabine/Anthracycline. (ekstern lenke)
• Gavasso, Sonia; Marøy, Tove Helene; Mosleth, Ellen Færgestad et al. (2012). Single cell pStat1 activation, a promising biomarker to evaluate neutralizing antibody effects in interferon-beta treated multiple sclerosis patients. (ekstern lenke)
• Hallenborg, Philip; Feddersen, Søren; Francoz, Sarah et al. (2012). Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. (ekstern lenke)
• Gullaksen, Stein-Erik Uriarte; Micoulet, Alexandre; Gjertsen, Bjørn Tore (2012). Deformation of acute myeloid leukaemia cells in micro-constriction array; a novel tool to study cell stress signalling. (ekstern lenke)
• Tsykunova, Galina; Reikvam, Håkon; Ahmed, Aymen B et al. (2012). Targeting of polo-like kinases and their cross talk with Aurora kinases - possible therapeutic strategies in human acute myeloid leukemia?. (ekstern lenke)
• Forthun, Rakel Brendsdal; Sengupta, Tanima; Skjeldam, Hanne Kim et al. (2012). Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. (ekstern lenke)

2011

• Gjertsen, Bjørn Tore (2011). Stratification of pediatric acute myeloid leukemia through cancer cell gene-expression profiling. (ekstern lenke)
• Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Øye, Ola Kristoffer et al. (2011). Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia. (ekstern lenke)
• Skavland, Jørn; Jørgensen, Katarina Mariann; Hadziavdic, Kenan et al. (2011). Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. (ekstern lenke)
• Tiron, Crina Elena; Gjerdrum, Christine; Høiby, Torill et al. (2011). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. (ekstern lenke)
• Fredly, Hanne Kristin; Ersvær, Elisabeth; Gjertsen, Bjørn Tore et al. (2011). Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis. (ekstern lenke)

2010

• Erikstein, Bjarte Skoe; Hagland, Hanne; Nikolaisen, Julie et al. (2010). Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. (ekstern lenke)
• Fredly, Hanne Kristin; Bjørnsen, Camilla I. Stapnes; Gjertsen, Bjørn Tore et al. (2010). Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia - a report of five cases. (ekstern lenke)
• Hatfield, Kimberley Joanne; Bedringaas, Siv Lise; Gjertsen, Bjørn Tore et al. (2010). OXYGEN LEVELS INFLUENCE THE CYTOKINE RELEASE PROFILE OF AML CELLS. (ekstern lenke)
• Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn et al. (2010). Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. (ekstern lenke)
• Skavland, Jørn; Hadziavdic, Kenan; Jonassen, Inge et al. (2010). Combined epigenetic and signal transduction therapy modulate specific signal transduction patterns in acute myeloid leukemia. (ekstern lenke)
• McCormack, Emmet Martin; Skavland, Jørn; Mujic, Maja et al. (2010). Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. (ekstern lenke)
• Hatfield, Kimberley Joanne; Bedringaas, Siv Lise; Ryningen, Anita et al. (2010). Hypoxia increases HIF-1 alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. (ekstern lenke)
• Erikstein, Bjarte Skoe; McCormack, Emmet Martin; Tronstad, Karl Johan et al. (2010). Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. (ekstern lenke)
• Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill et al. (2010). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. (ekstern lenke)
• Semaeva, Elvira; Tenstad, Olav; Skavland, Jørn et al. (2010). Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. (ekstern lenke)
• Hjelle, Sigrun Margrethe; Forthun, Rakel Brendsdal; Haaland, Ingvild et al. (2010). Clinical proteomics of myeloid leukemia. (ekstern lenke)

2009

• Wang, Jian; Tsinkalovsky, Oleg; Zhao, P et al. (2009). TARGETING THE TUMOR STROMA: A NOVEL THERAPEUTIC STRATEGY BASED ON SEPARATE ANALYSIS OF THE MALIGNANT AND STROMAL CELL COMPARTMENTS IN BRAIN TUMORS. (ekstern lenke)
• Christoffersen, Thoralf; Guren, Tormod K.; Spindler, Karen-Lise Garm et al. (2009). Cancer therapy targeted at cellular signal transduction mechanisms: strategies, clinical results, and unresolved issues. (ekstern lenke)
• Reikvam, Håkon; Olsnes, Astrid Marta; Gjertsen, Bjørn Tore et al. (2009). Nuclear Factor-kappaB Signaling: A Contributor in Leukemogenesis and a Target for Pharmacological Intervention in Human Acute Myelogenous Leukemia. (ekstern lenke)
• Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem et al. (2009). Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia. (ekstern lenke)
• Ryningen, Anita; Stapnes, Camilla I; Lassalle, Philippe et al. (2009). A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid. (ekstern lenke)
• Oveland, Eystein; Gjertsen, Bjørn Tore; Wergeland, Line et al. (2009). Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. (ekstern lenke)
• Hofmann, Matthias; McCormack, Emmet Martin; Mujic, Maja et al. (2009). Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model. (ekstern lenke)
• Olsnes, Astrid Marta; Ersvær, Elisabeth; Ryningen, Anita et al. (2009). The protein kinase C agonist PEP005 increases NF-kB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells. (ekstern lenke)
• Gjertsen, Bjørn Tore (2009). Er høyt hemoglobinnivå farlig?. (ekstern lenke)
• Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth et al. (2009). Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. (ekstern lenke)
• Christoffersen, Thoralf; Gjertsen, Bjørn Tore; Engebråten, Olav et al. (2009). Signalhemmere. (ekstern lenke)
• Stapnes, Camilla I; Gjertsen, Bjørn Tore; Reikvam, Håkon et al. (2009). Targeted therapy in acute myeloid leukaemia: current status and future directions. (ekstern lenke)
• Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth et al. (2009). Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. (ekstern lenke)
• Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne et al. (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Bredholt, Therese; Neppelberg, Evelyn et al. (2009). Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. (ekstern lenke)

2008

• Kirkeleit, Jorunn; Riise, Trond; Gjertsen, Bjørn Tore et al. (2008). Effects of benzene on human hematopoiesis. (ekstern lenke)
• McCormack, Emmet Martin; Bruserud, Øystein; Gjertsen, Bjørn Tore (2008). Review: genetic models of acute myeloid leukaemia. (ekstern lenke)
• Gjertsen, Bjørn Tore; McCormack, Emmet Martin (2008). Erythropoietin a safe bet in haemorrhagic shock?. (ekstern lenke)
• Bruserud, Øystein; Ersvær, Elisabeth; Olsnes, Astrid Marta et al. (2008). Anticancer Immunotherapy in Combination with Proapoptotic Therapy. (ekstern lenke)
• Gavasso, Sonia; Skavland, Jørn; Gjertsen, Bjørn Tore et al. (2008). Interferon-beta signal transduction, multiple sclerosis and auto-antibodies. (ekstern lenke)
• Wergeland, Line; Oveland, Eystein; Sjøholt, Gry et al. (2008). FLT3 internal tandem duplication involving its libiquitin dependent endocytosis motif suspend modulation by HDM2 and are associated with inferior survival in AML. (ekstern lenke)
• McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid et al. (2008). Evaluation of combinational therapy of MDM2-antagonist nutlin-3 and HDAC-inhibitor valproic acid in acute myeloid leukemia in vitro and in vivo. (ekstern lenke)
• Ryningen, Anita; Stapnes, Camilla I; Paulsen, Kristin et al. (2008). In vivo biological effects of ATRA in the treatment of AML. (ekstern lenke)
• Hatfield, Kimberley Joanne; Hovland, Randi; Øyan, Anne Margrete et al. (2008). Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels. (ekstern lenke)
• Gjertsen, Bjørn Tore; Lorens, James (2008). Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics. (ekstern lenke)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Dimba, Elisabeth Anne Okumu et al. (2008). Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. (ekstern lenke)
• Gausdal, Gro; Gjertsen, Bjørn Tore; McCormack, Emmet Martin et al. (2008). Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. (ekstern lenke)

2007

• Ånensen, Nina; Øyan, Anne Margrete; Huseby, Sjur et al. (2007). Early gene expression of acute myeloid leukemia in response to chemotherapy. (ekstern lenke)
• Gjertsen, Bjørn Tore; Bredholt, Therese; Ånensen, Nina et al. (2007). Bcl-2 antisense in the treatment of human malignancies: A delusion in targeted therapy. (ekstern lenke)
• Øyan, Anne Margrete; Bø, Trond Hellem; Jonassen, Inge et al. (2007). Global gene expression in classification, pathogenetic understanding and identification of therapeutic targets in Acute Myeloid Leukemia. (ekstern lenke)
• Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn Iren et al. (2007). Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. (ekstern lenke)
• Parlati, Francesco; Aujay, Monette; Bedringaas, Siv Lise et al. (2007). Anti-tumor activity of immunoproteasome selective inhibitors. (ekstern lenke)
• Stapnes, Camilla I; Ryningen, Anita; Hatfield, Kimberley Joanne et al. (2007). Linking susceptibility to histone deactylase inhibitors and basal gene expression profiles in acute myeloid leukaemia. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

1. Omsland M, Vibeke Andresen V, Gullaksen SE, Ayuda-Durán P, Popa M, Hovland R, Brendehaug A, Enserink J, McCormack E, Gjertsen BT. Interferon alpha and tyrosine kinase inhibitors increase tunneling nanotubes (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines. FASEB J. 2020 34(3):3773-3791. Citations: 3. IF 5.191. ••Impact: The first report on upregulation of TNT by kinase inhibitors and indicate that the old anti-leukemic interferon-alpha act share the same mechanism as kinase inhibitors. The effect of kinase inhibitor on TNT is an example of functional regulation by small molecules.

 

2.  Gullaksen SE, Skavland J, …, Gjertsen BT. Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukaemia treated with nilotinib. Haematologica 2017; 102:1361-1367. Citations: 13. IF 5.814. •••Impact: This paper introduces mass cytometry panel as a core technology for single cell monitoring in clinical trials. Prognostication based on single cell analysis at 7 days indicate molecular response (tumour load) at 18 months on targeted therapy that predispose to cardiovascular disease.

 

3. Engen C, Hellesøy M, Grob T, Löwenberg B, Valk PJM, Gjertsen BT. Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis. Mol Oncol. 2021 Jun 8. doi: 10.1002/1878-0261.13035. Citations: 0. IF 6.603. ••Impact: Prognostication based on FLT3 genetics seems only to be valid for females. Leukaemia cell samples are distinct in females and males in terms of gene expression and ex vivo drug sensitivity, in addition to the previously known sex depended mutational profile of leukaemia.

 

4. Engen C, Hellesøy M, Grob T, Hinai AA, Brendehaug A, Wergeland L, Bedringaas SL, Hovland R, Valk PJM, Gjertsen BT. FLT3-ITD mutations in acute myeloid leukaemia - Molecular characteristics, distribution and numerical variation. Mol Oncol. 2021 Apr 5. doi: 10.1002/1878-0261.12961. Citations: 0. IF 6.603. •Impact: This report demonstrates the heterogeneity of FLT3 mutations in AML, and raise a question about more accurate tools for therapy monitoring for varying cell populations in the same patient.

 

5. Forthun RB, Aasebø E, Rasinger JD, Bedringaas SL, Berven F, Selheim F, Bruserud Ø, Gjertsen BT. Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia. J Proteomics. 2018 Feb 20;173:32-41. Citations: 7. IF 3.537. ••Impact: Underpinning data on signaling networks affected by the phenotypes and genetics in AML.

 

6. McCormack E, Mujic M, Osdal T, Bruserud Ø, Gjertsen BT. Multiplexed monoclonal antibodies: A new strategy in preclinical time domain imaging of acute myeloid leukemia. Citations: 15. IF 9.060. Blood. 2013;121:e34-42. Impact: outline in vivo multiplexing imaging in leukemia. •••Impact: Seminal paper that point in the direction of multiplex analysis in medical imaging.

             

7. Sulen A, Lygre SH, Hjelle SM, Hollund BE, Gjertsen BT. Elevated monocyte phosphorylated p38 in nearby employees after a chemical explosion. Sci Rep. 2016 Jul 6;6:29060. Citations: 1. IF 4.259. ••Impact: Demonstrate that single cell signaling profiling in a cross-sectional healthy survey can be used to examine exposure to smoke and correlate with occupational activity of exposure.

 

8. McCormack E, Haaland I, …, Gjertsen BT. Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. Leukemia. 2012 May;26(5):910-7. Citations: 63. IF 11.528. •Impact: Developing low toxicity combination and use of protein biomarkers to monitor therapy response.  

 

9. Andresen V, …, Gjertsen BT. Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Cell Death Dis. 2016 Dec 1;7(12):e2497. Citations: 8. IF 5.965. •Impact: Targeted therapy concept that point in the direction of functional diagnostics.

 

10. Ånensen N, ..., Gjertsen BT. Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. Oncogene. 2012;31(12):1533-45. Citations: 44. IF 5.965. •••Impact: First report on protein p53 isoform analysis in prognostication demonstrating consistency between p53 isoform profiles, genomics, therapy response and survival in AML.