Mitt forskningsmål er å karakterisere og bedre forstå signalveier involvert i endokrine sykdommer, fokusert på diabetesutvikling og adreno-gonadal utvikling, gjennom å studere modeller basert på induserte pluripotente stamceller (iPSCs) fra pasienter med monogen eller multifaktoriell sykdom.

https://raederlab.w.uib.no/

 

https://raederlab.wordpress.com/

https://www.facebook.com/raederlab/

Jeg underviser medisinstudenter i pediatrisk termin, for tiden i MED12 om vekst- og pubertetsforstyrrelser. Jeg har tidligere hatt forelesningene "Intoxication" og "Fluid Therapy" (Klinisk institutt 2).

Jeg underviser ernæringsstudenter i metabolske sykdommer (NUC352, Klinisk institutt K1).

Jeg bidrar også inn på masterundervisning i BMED330 (Institutt for biomedisin)

Jeg leder to elektive kurs:

-ELMED223: Innovasjon og Entrepenørskap

-ELMED303: Fremtidsmedisin

Jeg deltar også i organiseringen av kurset "Pediatrisk Endokrinologi" for spesialistkandidater i Pediatri og foreleser der om calciummetabolismen og sykdommer i somatisk kjønnsutvikling. 

 

2024

• Seljeseth, Ingvild Müller; Sørlie, Henrik; Grønli, Janne et al. (2024). Nightly Sleep and Daily Job Task Performance: An Experience Sampling Study. (ekstern lenke)
• Wang, Chencheng; Abadpour, Shadab; Olsen, Petter Angell et al. (2024). Glucose Concentration in Regulating Induced Pluripotent Stem Cells Differentiation Toward Insulin-Producing Cells. (ekstern lenke)
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Aleksandra et al. (2024). Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling. (ekstern lenke)

2023

• Ali, Hassan Abdel-Raouf Abdel-Wahab; Suliman, Salwa; Osman, Tarig Al-Hadi et al. (2023). Xeno-free generation of human induced pluripotent stem cells from donor-matched fibroblasts isolated from dermal and oral tissues. (ekstern lenke)
• Scholz, Hanne; Ræder, Helge (2023). Response to Comment on Carrasco et al. Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes 2022;71:862-869. (ekstern lenke)

2022

• Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Scholz, Hanne et al. (2022). Molecular mechanisms affecting islet like cell fate acquisition in differentiating iPSC derived β-like cells”. (ekstern lenke)
• Sandvei, Marie Søfteland; Jacobsen, Geir Wenberg; Stien, Marianne Heldal et al. (2022). A national intercalated medical student research program –student perceptions, satisfaction, and factors associated with pursuing a PhD. (ekstern lenke)
• Myklebust, Mette Pernille; Søviknes, Anne Mette; Halvorsen, Ole Johan et al. (2022). MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer. (ekstern lenke)
• Fernandez, Manuel Carrasco; Wang, Chencheng; Søviknes, Anne Mette et al. (2022). Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. (ekstern lenke)
• Kahraman, Sevim; Dirice, Ercument; Basile, Giorgio et al. (2022). Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8. (ekstern lenke)
• Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana et al. (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. (ekstern lenke)

2021

• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). Glucose during in vitro pancreatic beta cells regeneration: friends or for?. (ekstern lenke)
• Wang, Chencheng; Abadpour, Shadab; Aizenshtadt, Alexandra et al. (2021). 402.2: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells. (ekstern lenke)
• Choi, Man Hung; Tjora, Erling; Forthun, Rakel Brendsdal et al. (2021). KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases. (ekstern lenke)
• Hoareau, Laurence; Engelsen, Agnete ; Aanerud, Marianne et al. (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. (ekstern lenke)
• Ghila, Luiza; Legøy, Thomas Aga; Mathisen, Andreas Frøslev et al. (2021). Chronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human ipsc-derived pancreatic progenitors. (ekstern lenke)

2020

• Gupta, Manoj K.; Vethe, Heidrun; Softic, Samir et al. (2020). Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells. (ekstern lenke)
• Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab et al. (2020). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling . (ekstern lenke)
• Ghila, Luiza; Bjørlykke, Yngvild; Legøy, Thomas Aga et al. (2020). Bioinformatic analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4α mutation. (ekstern lenke)

2019

• Bjørlykke, Yngvild; Søviknes, Anne Mette; Hoareau, Laurence et al. (2019). Reprogrammed cells display distinct proteomic signaturesAssociated with colony morphology variability. (ekstern lenke)
• Loo, Larry Sai Weng; Vethe, Heidrun; Soetedjo, Andreas Alvin Purnomo et al. (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. (ekstern lenke)
• Ng, Natasha Hui Jin; Jasmen, Joanita Binte; Lim, Chang Siang et al. (2019). HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells. (ekstern lenke)
• Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun et al. (2019). In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. (ekstern lenke)
• Furuyama, Kenichiro; Chera, Simona; van Gurp, Leon et al. (2019). Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (ekstern lenke)
• Vethe, Heidrun; Ghila, Luiza; Berle, Magnus et al. (2019). The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation. (ekstern lenke)
• Vethe, Heidrun; Legøy, Thomas Aga; Abadpour, Shadab et al. (2019). Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. (ekstern lenke)

2018

• Johansson, Bente Berg; Fjeld, Karianne; el Jellas, Khadija et al. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. (ekstern lenke)
• Jacobsen, Geir Wenberg; Ræder, Helge; Stien, Marianne Heldal et al. (2018). Springboard to an academic career - A national medical student research program. (ekstern lenke)

2017

• Vethe, Heidrun; Bjørlykke, Yngvild; Ghila, Luiza et al. (2017). Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. (ekstern lenke)
• Verheggen, Kenneth; Ræder, Helge; Berven, Frode et al. (2017). Anatomy and evolution of database search engines—a central component of mass spectrometry based proteomic workflows. (ekstern lenke)

2016

• Rafaelsen, Silje Hjorth; Johansson, Stefan; Ræder, Helge et al. (2016). Hereditary hypophosphatemia in Norway: A retrospective population-based study of genotypes, phenotypes, and treatment complications. (ekstern lenke)
• Hernandez Sanchez, Luis Francisco; Aasebø, Elise; Selheim, Frode et al. (2016). Systemic Analysis of Regulated Functional Networks. (ekstern lenke)
• Vaudel, Marc; Barsnes, Harald; Ræder, Helge et al. (2016). Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies. (ekstern lenke)
• Teo, Adrian Kee Keong; Lau, Hwee Hui; Valdez, Ivan Achel et al. (2016). Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. (ekstern lenke)
• Vaudel, Marc; Verheggen, Kenneth; Csordas, Attila et al. (2016). Exploring the potential of public proteomics data. (ekstern lenke)

2015

• Helgeland, Øyvind; Hertel, Jens Kristoffer; Molven, Anders et al. (2015). The chromosome 9p21 CVD- and T2D-associated regions in a Norwegian population (the HUNT2 survey). (ekstern lenke)

2014

• Bjørlykke, Yngvild; Vethe, Heidrun; Vaudel, Marc et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. (ekstern lenke)
• Rafaelsen, Silje Hjorth; Johansson, Stefan; Ræder, Helge et al. (2014). Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. (ekstern lenke)
• Ræder, Helge; McAllister, Fiona E.; Tjora, Erling et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (ekstern lenke)

2013

• Teo, Adrian K.K.; Windmueller, Rebecca; Johansson, Bente Berg et al. (2013). Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young. (ekstern lenke)
• Søvik, Oddmund; Irgens, Henrik Underthun; Molnes, Janne et al. (2013). Monogenetic diabetes mellitus in Norway :. (ekstern lenke)
• Ræder, Helge; Vesterhus, Mette; El Ouaamari, Abdelfattah et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (ekstern lenke)
• Rafaelsen, Silje Hjorth; Ræder, Helge; Fagerheim, Anne Kristine et al. (2013). Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. (ekstern lenke)
• Tjora, Erling; Wathle, Gaute K; Erchinger, Friedemann et al. (2013). Exocrine pancreatic function in hepatocyte nuclear factor 1 beta-maturity-onset diabetes of the young (HNF1B-MODY) is only moderately reduced: compensatory hypersecretion from a hypoplastic pancreas. (ekstern lenke)
• Tjora, Erling; Wathle, Gaute K; Engjom, Trond et al. (2013). Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations. (ekstern lenke)

2012

• Gonc, E. Nazli; Ozturk, Burcu Bulum; Haldorsen, Ingfrid S. et al. (2012). HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. (ekstern lenke)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (ekstern lenke)
• Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus (2012). Skreddersydd medisin eller narsissomikk?. (ekstern lenke)

2011

• Hertel, Jens Kristoffer; Johansson, Stefan; Ræder, Helge et al. (2011). Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study). (ekstern lenke)
• Thanabalasingham, Gaya; Shah, Nabi; Vaxillaire, Martine et al. (2011). A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. (ekstern lenke)
• Haldorsen, Ingfrid S.; Ræder, Helge; Vesterhus, Mette et al. (2011). The role of pancreatic imaging in monogenic diabetes. (ekstern lenke)
• Johansson, Bente Berg; Torsvik, Janniche; Bjørkhaug, Lise et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (ekstern lenke)

2010

• Vesterhus, Mette; Ræder, Helge; Kurpad, Amarnath J et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (ekstern lenke)
• Njølstad, Pål Rasmus; Hertel, Jens Kristoffer; Søvik, Oddmund et al. (2010). Fremskritt innen diabetesgenetikk. (ekstern lenke)
• Torsvik, Janniche; Johansson, Stefan; Johansen, Anders et al. (2010). Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes. (ekstern lenke)
• Allen, Hana Lango; Johansson, Stefan; Ellard, Sian et al. (2010). Polygenic risk variants for Type 2 Diabetes susceptibility modify age at diagnosis in Monogenic HNF1A Diabetes. (ekstern lenke)

2008

• Fjeld, Karianne; Torsvik, Janniche; Johansson, Stefan et al. (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. (ekstern lenke)
• Vesterhus, Mette; Haldorsen, Ingfrid Salvesen; Ræder, Helge et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (ekstern lenke)
• Sagen, Jørn V.; Bjørkhaug, Lise; Molnes, Janne et al. (2008). Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. (ekstern lenke)
• Vesterhus, Mette; Ræder, Helge; Aurlien, Harald et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (ekstern lenke)
• Vesterhus, Mette; Ræder, Helge; Johansson, Stefan et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (ekstern lenke)
• Ræder, Helge; Bjerknes, Robert (2008). X-bundet hypofosfatemisk rakitt: Ny kunnskap om patofysiologi, behandling og oppfølging. (ekstern lenke)
• Ræder, Helge; Shaw, Nick; Netelenbos, C. et al. (2008). A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet. (ekstern lenke)
• Eide, Stig Åge; Ræder, H; Ræder, Helge et al. (2008). Prevalence of HNF1A (MODY3) mutations in a Norwegian population (the HUNT2 Study). (ekstern lenke)
• Haldorsen, Ingfrid Salvesen; Vesterhus, Mette; Ræder, Helge et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (ekstern lenke)
• Hertel, Jens Kristoffer; Johansson, Stefan; Ræder, H et al. (2008). Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). (ekstern lenke)
• Molven, Anders; Ringdal, Monika; Nordbø, Anita-Merete et al. (2008). Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. (ekstern lenke)

2007

• Vesterhus, Mette; Johansson, Stefan; Ræder, Helge et al. (2007). Pancreatic exocrine deficiency is common in MODY 3. (ekstern lenke)
• Johansson, Stefan; Ræder, Helge; Eide, Stig Åge et al. (2007). Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. (ekstern lenke)
• Ræder, Helge; Haldorsen, Ingfrid Salvesen; Ersland, Lars et al. (2007). Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-Ester lipase. (ekstern lenke)

2006

• Ræder, Helge; Njølstad, Pål Rasmus (2006). Ny type diabetes. (ekstern lenke)
• Raeder, Helge; Ræder, Helge; Bjorkhaug, Lise et al. (2006). A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes - Studies of HNF4A variants in the Norwegian MODY registry. (ekstern lenke)
• Ræder, Helge; Johansson, Stefan; Holm, Pål I. et al. (2006). Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)
• Ræder, Helge (2006). Novel monogenic causes of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)

2005

• Gundersen, Lise Bj.; Johansson, Stefan; Ræder, Helge et al. (2005). Molekylærgenetisk diagnostikk ved diabetes mellitus. (ekstern lenke)

2004

• Sagen, Jørn V.; Ræder, Helge; Hathout, Eba et al. (2004). Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2 - Patient characteristics and initial response to sulfonylurea therapy. (ekstern lenke)

2002

• Ræder, Helge; Ræder, Maria; Njølstad, Pål Rasmus (2002). Klinisk molekylærmedisin:DNA-sekvensering. (ekstern lenke)

1996

• Ræder, Helge; Aaberg, M.; Omvik, Per (1996). Unchanged 24-hour ambulatory blood pressure during short-term salt restriction and salt repletion in normotensive subjects. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

https://scholar.google.com/citations?user=ecPm_OoAAAAJ&hl=en