News archive for Neurotargeting Research Group

GADL1, a novel enzyme to improve athletic performance (09.02.2021)

Carnosine plays an important roles as antioxidant, pH buffer, and neuromodulator and recently received increasing attention as biomarker for many disease states such as Alzheimer disease and Parkinson disease. The Neurotargeting group at the Department of Biomedicine discovered a novel enzyme, Glutamate Decarboxylase Like 1 (GADL1) that plays a role in carnosine production.

Structures of two CMT mutation targets revealed (02.02.2021)

Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans, linked to mutations in dozens of different genes. Two of these genes encode the proteins GDAP1 and NDRG1. We have solved the crystal structures of these two proteins, in order to better understand their structure, function, and involvement in disease.