Orthodontically induced root and alveolar bone resorption: Inhibitory effect of systemic doxycycline administration in rats
Main content
The aim of this study was to investigate the effect of systemic administration of low dose doxyclycline (DC) on orthodontic root resorption. The effect on alveolar bone, the cell population involved, and the amount of tooth movement were also evaluated.
Orthodontically induced root resorption was performed in rats, by exerting 50 g force on maxillary first molars for 7 – 14 days. Half of the animals (28 rats) received systemic administration of DC before insertion of the orthodontic appliance. The compressed areas at the mesial aspect of the distopalatal roots were histomorphometrically evaluated. The results revealed a significant less root resorption in rats with DC administration. The number of TRAP-positive cells (odontoclasts, osteoclasts, giant cells) was significantly reduced as compared to non-DC administrated group. In conclusion, systemic administration of low-dose DC in rats may have an inhibitory effect on orthodontically induced resorptive activity.
People:
Pongsri Brudvik, Professor, DDS, Lic.odont, PhD, Department of Clinical Dentistry – Orthodontics, University of Bergen
Polbhat Tripuwabhrut, PhD candidate, DDS, Department of Clinical Dentistry – Center for Dental Clinical Research, University of Bergen
