Selected recent publications

Peripheral membrane binding

Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: When aromatic amino acids matter. A.S. Schillinger, C. Grauffel, H.M. Khan, O. Halskau, N. Reuter*. Biochim Biophys Acta - Biomembranes (2014) 1838(12): 3191-3202 10.1016/j.bbamem.2014.09.003

Cation-pi interactions as lipid-specific anchors for phosphatidylinositol-specific phospholipase-C. C.Grauffel, B.Yang, T.He, M.F. Roberts, A.Gershenson, N.Reuter*,  Journal of the American Chemical Society (2013) 135(15):5740-50  10.1021/ja312656v

Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding? J.Cheng, S. Karri, C.Grauffel, F.Wang, N.Reuter, M.F. Roberts, P.L.Wintrode, A.Gershenson*, Biophysical Journal (2013) 104: 1-11 10.1016/j.bpj.2012.11.015

Collective motions in proteins

WEBnm@ v2.0: Web server and services for comparing protein flexibility.  S.P. Tiwari, E.Fuglebakk*, S.M.Hollup, L.Skjaerven, T.Cragnolini, S.H.Grindhaug, K.M.Tekle, N.Reuter*. BMC Bioinformatics (2014) 15: 6597 10.1186/s12859-014-0427-6

Evolution of oligomeric state through allosteric pathways that mimic ligand binding. T.Perica,Y.Kondo,S.P.Tiwari, S.H.McLaughlin, K.R.Kemplen, X.Zhang, A.Steward, N.Reuter, J.Clarke, S.A.Teichmann. Science. 2014, 346(6216) 10.1126/science.1254346

•• Comparing the Intrinsic Dynamics of Multiple Protein Structures Using Elastic Network Models E. Fuglebakk, S.P. Tiwari, N. Reuter*. Biochim Biophys Acta - General Subjects (2014) [review article] in press 10.1016/j.bbagen.2014.09.021 

Measuring and comparing structural fluctuation patterns in large protein datasets. E.Fuglebakk, J.Echave, N.Reuter*. Bioinformatics (2012) 28(19):2431-40 10.1093/bioinformatics/bts445
 

NSPs in chronic inflammation

Reversible Ketomethylene-Based Inhibitors of Human Neutrophil Proteinase 3 A.Budnjo, S.Narawane, C.Grauffel, A.S. Schillinger, T. Fossen, N.Reuter*, B.E.Haug*. Journal of Medicinal Chemistry (2014) 57(22):9396–9408 10.1021/jm500782s

In silico design, synthesis and assays of specific substrates for Proteinase 3: influence of fluorogenic and charged groups. S.Narawane, A.Budnjo, C.Grauffel, B.E.Haug*, N.Reuter*. Journal of Medicinal Chemistry (2014) 57(3):1111-1115 10.1021/jm401559r

•• Structures of human proteinase 3 and neutrophil elastase--so similar yet so different. E.Hajjar, T.Broemstrup, C.Kantari, V.Witko-Sarsat, N.Reuter, Febs Journal (2010), 277, 2238-54. [review article] 10.1111/j.1742-4658.2010.07659.x