Sleep apnea and comorbid somatic and mental disorders

This project uses data from the Register of Sleep Medicine at Haukeland University Hospital and includes patients with suspected sleep disorders. The register primarily comprises patients with sleep apnea, but also a minor patient group with severe hypersomnia is included. Furthermore, the register contains follow-up data from patients who have received CPAP- or other treatments at the clinic. Several articles have been published and many PhD candidates are working with data from the register.

PhD projects

• Patient specific factors predicting adherence and treatment effect of oral appliance therapy in obstructive sleep apnea. PhD candidate: Kjersti Gjerde:  Period: 2017-2021
• Consequences of obstructive lung function and sleep apnea; trifle or tragedy? PhD candidate (the Dual competency Program: Trygve M Johannesen.  Period: 2017-2025
• Acoustic pharyngometry to improve the treatment effect of oral appliance therapy in obstructive sleep apnea patients. PhD candidate (the Dual competency Program). Period: 2018-2026
• Obstructive sleep apnea and comorbidity: Treatment outcomes, influence on other sleep disorders, and the impact on inflammatory and metabolic biomarkers”. PhD candidate: Ragnhild Stokke Lundetræ. Period 2022- 2026.

Publications

1. Johansson A, Gjerde K, Lehmann S, Bjorvatn B, Al-azawy K, Gulati S, Berge ME. Oral appliance therapy for sleep apnoea Tidsskr Nor Laegeforen. 2014 May .
2. Gjerde K, Lehmann S, Berge ME, Johansson AK, Johansson A. J Oral Rehabil. Oral appliance treatment in moderate and severe obstructive sleep apnoea patients non-adherent to CPAP.  2016 Apr;43(4):249-58. doi: 10.1111/joor.12376. Epub 2015 Dec 27.
3. Gjerde K, Lehmann S, Naterstad IF, Berge ME, Johansson A. Reliability of an adherence monitoring sensor embedded in an oral appliance used for treatment of obstructive sleep apnoea. J Oral Rehabil. 2018 Feb;45(2):110-115. doi: 10.1111/joor.12584. Epub 2017 Dec 12. PMID: 29090478
4. Storesund A, Johansson AA, Bjorvatn B, Lehmann S. Oral appliance treatment outcome can be predicted by continuous positive airway pressure in moderate to severe obstructive sleep apnea. Sleep & Breathing 2018; 22: 385-392. PMID: 29067558. Nivå 1.
5. Bjorvatn B, Rajakulendren N, Lehmann S, Pallesen S. Increased severity of obstructive sleep apnea is associated with less anxiety and depression. J Sleep Research 2018; 27: e12647. PMID: 29193447.
6. Tveit RL, Lehmann S, Bjorvatn B. Prevalence of several somatic diseases depends on the presence and severity of obstructive sleep apnea. PLoS ONE 2018; 13(2): e0192671. PMID: 29474482.
7. Lundetræ RS, Saxvig IW, Pallesen S, Aurlien H, Lehmann S, Bjorvatn B. Prevalence of parasomnias in patients with obstructive sleep apnea, a registry-based cross-sectional study. Frontiers in Psychology 2018; 9: 1140. PMID: 30026716.
8. Bjorvatn B, Berge T, Lehmann S, Pallesen S, Saxvig IW. No effect of a self-help book for insomnia in patients with obstructive sleep apnea and comorbid chronic insomnia – a randomized controlled trial. Frontiers in Psychology 2018; 9:2413.
9. Lundetræ RS, Saxvig IW, Lehmann S, Bjorvatn B. Effect of continuous positive airway pressure on symptoms of anxiety and depression in patients with obstructive sleep apnea. Sleep & Breathing 2021; 25: 1277-1283. PMID: 33098538.
10. Lundetræ RS, Saxvig IW, Aurlien H, Lehmann S, Bjorvatn B. Effect of continuous positive airway pressure on symptoms and prevalence of insomnia in patients with obstructive sleep apnea. A longitudinal study. Frontiers in Psychology 2021; 12: 691495. PMID: 34367017.
11. Opsahl, Ulrik Leidland; Johansson, Anders; Berge, Morten ; Opsahl, Per; Lehmann, Sverre. (2018). Akustisk pharyngometri for bedre resultat av behandling med søvnapnéskinner. Den norske tannlegeforenings tidende. 264-267.
12. Opsahl UL, Berge M, Lehmann S, Bjorvatn B, Opsahl P, Johansson A. Acoustic pharyngometry – a new method to facilitate oral appliance therapy. Journal of Oral Rehabilitation 2021; 48: 601-613. PMID: 33314265.
13. Gjerde K, Lehmann S, Bjorvatn B, Berge M, Thuen F, Berge T, Johansson A. Partner perceptions are associated with objective sensor-measured adherence to oral appliance therapy in obstructive sleep apnea. Journal of Sleep Research 2022; 31; e13462. PMID: 34490690.
14. Saeed S, Romarheim A, Mancia G, Saxvig IW, Gulati S, Lehmann S, Bjorvatn B. Characteristics of hypertension and arterial stiffness in obstructive sleep apnea: A Scandinavian experience from a prospective study of 6408 normotensive and hypertensive patients. Journal of Clinical Hypertension 2022; 24: 385-394. PMID: 35156757
15. Mjelle KES, Lehmann S, Saxvig IW, Gulati S, Bjorvatn B. Association of excessive sleepiness, pathological fatigue, depression and anxiety with different severity levels of obstructive sleep apnea. Frontiers in Psychology 2022; 13: 839408. PMID: 35432136
16. Jonassen TM, Bjorvatn B, Saxvig IW, Eagan TML, Lehmann S. Clinical information predicting severe obstructive sleep apnea: A cross-sectional study of patients waiting for sleep diagnostics. Respiratory Medicine 2022; 197: 106860. PMID: 35490509
17. Jonassen, Trygve Muller; Eagan, Tomas Mikal; Bjorvatn, Bjørn; Lehmann, Sverre. (2016). Associations between obstructive lung disease and symptoms of obstructive sleep apnoea in a general population. Clinical Respiratory Journal. 31-39.
18. Johansson, Anders; Bjorvatn, Bjørn; Saxegaard, Erik; Gjerde, Kjersti; Berge, Morten Eirik; Lehmann, Sverre; Opsahl, Ulrik Leidland. (2018). Stor interesse for odontologisk søvnmedisin og søvnapné i Norge. Den norske tannlegeforenings tidende. 202-204
19. Saeed S, Romarheim A, Solheim E, Bjorvatn B, Lehmann S. Cardiovascular remodeling in obstructive sleep apnea: focus on arterial stiffness, left ventricular geometry and atrial fibrillation. Expert Review of Cardiovascular Therapy 2022; 20: 6; 455-464. PMID: 35673889