Yo

Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Cerebellar ataxia

Most frequently associated tumors:
- Breast cancer
- Ovarian cancer
- Uterus cancer

The onconeuronal Yo antibody binds to two different proteins; cerebellar degeneration-related protein 2 (CDR2) and 2-Like (CDR2L). These proteins are quite similar and have around 50 % sequence homology. Quite little is known about their location, interaction partners, regulation and function in neuronal cells. In the cerebellum the proteins are expressed in Purkinje neurons and cells of the moleculare layer (probably stellate and/or basket cells), but they are also expressed in neuronal cells in the midbrain (PMID:27253404).