DC 7: Design of compounds targeting the group II intron of Enterobacteriales and Candida
Research field: Molecular Modeling and Simulations, Computer-Aided Drug Design.
Hovedinnhold
PhD project description:
PhD project description: The candidate will make use of equilibrium and enhanced sampling molecular dynamics simulations to investigate the landscape of the group II introns and potential new ligands. Structure-based and computer-aided approaches will be used to rationally drive the design compounds targeting RNA. Physico-chemical properties of the compounds will be computationally evaluated, like solubility and stability measures, to select the best compounds.
Supervisor: Marco De Vivo
Host institute: Fondazione Istituto Italiano di Tecnologia, Italy
Secondments planned: AstraZeneca Sweden
Doctoral program: PhD Programmes attendance at the University of Bologna.
PhD details - Biotechnological, Biocomputational, Pharmaceutical and Pharmacological Sciences — University of Bologna (unibo.it)
