Genetic studies of Fc gamma receptors in Sjögren´s syndrome
Hovedinnhold
FcΥ receptors are glycoproteins that bind the Fc region on IgG. Genetic variations in the low-affinity receptors have been associated with different diseases. Single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in FcΥR can contribute to interindividual differences and differences in gene expression. For instance has CNVs in the FCGR3B gene been associated with glomerulonephritis in systemic lupus erythematosus (SLE) and with increased susceptibility to other autoimmune diseases. The project aims at investigating polymorphisms and CNV in genes encoding the FcΥ receptors in patients with Sjögren´s syndrome.
Collaborators:
Professor Anne Isine Bolstad, Department of Clinical Dentistry- Periodontics,
Professor Johan G. Brun, Institute of Medicine, Section for Rheumatology,
Dr. Silke Appel, Broegelmann Research Laboratory, The Gade Institute.
PhD fellow: Karstein Haldorsen, MD.
https://www.uib.no/personer/Karstein.Haldorsen
https://www.uib.no/personer/Anne.Bolstad
https://www.uib.no/personer/Johan.Brun
https://www.uib.no/personer/Silke.Appel
https://www.uib.no/Broegelmann