CCBIO Web Seminar – JianFeng Chen

Speaker: Professor JianFeng Chen, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.

Title: Regulation of immune cell trafficking by extracellular microenvironment

Chairperson: Donald Gullberg

Abstract: 

Immune surveillance and host defence depend on the precisely regulated tissue-specific trafficking of lymphocytes. α4 integrins (α4β7 and α4β1) are heterodimeric lymphocyte homing receptors that mediate lymphocyte adhesion and migration by interacting with their ligands. The dynamic regulation of integrin-ligand binding by extracellular stimuli is essential to integrin-mediated lymphocyte trafficking. One research interest in my lab is the regulation of integrin adhesion and signaling by different extracellular microenvironment factors. My talk will focus on two of our most recent findings: the switch of integrin ligand specificity by different chemokines, and the regulation of integrin-mediated lymphocyte adhesion and migration by febrile temperature. 

Short bio:

PhD Jianfeng Chen is Professor at Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of sciences (CAS), Shanghai. Dr Chen obtained his PhD at CAS Shanghai in 2001 and was then research fellow in the laboratory of Professor Timothy Springer at Harvard Medical School 2001-2007, before returning to Shanghai in 2007. He is a leading integrin scientist with publications in PNAS, J. Biol.Chem., Mol. Cancer,  J. Cell Biol., Dev. Cell, and Immunity. For details about his research focus please see: http://www.sibcb.ac.cn/ePI.asp?id=3

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