DATURA – Better treatment for patients with tuberculosis and HIV co-infections
The project aims to assess whether an intensified initial TB treatment can increase survivability in hospitalised, HIV-infected adults and adolescents compared to the standard TB treatment regime.
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The Datura project is a multidisciplinary international research project involving four countries in four different sub-Saharan regions, two countries in Southeast Asia and two European academic institutions. It is studying the effect of using a modified TB treatment protocol in severely immunosuppressed TB patients. The name, Datura, is an acronym for: Determination of Adequate TUberculosis Regimen in Adults and Adolescents hospitalised with HIV-associated severe immune suppression.
The project is a collaboration between researchers in Norway, France, Zambia, Guinea, Cameroon, Uganda, Cambodia and Mozambique. It is co-ordinated by a research team at the Centre Hospitalier Universitaire de Montpellier in France. The project is funded by the European & Developing Countries Clinical Trials Partnership (EDCTP). Datura also addresses SDG Goal 3, target 3.3, aiming to end the epidemics of AIDS and TB, among others, by 2030.
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About the project
Project name: Determination of Adequate TUberculosis Regimen in Adults and Adolescents hospitalised with HIV-associated severe immune suppression
Period: 2020-
Funding: This project is primarily funded by EDCTP2. EDCTP2 number: RIA2018CO-2515
Project coordinator: Dr Didier LAUREILLARD, Prof.François-Xavier BLANC.
Co-coordinator UiB: Sven Gudmund Hinderaker
Countries: Zambia, Guinea, Uganda, Cameroon, Cambodia, Vietnam
Partners: Institut national de la santé et de la recherche médicale, INSERM (UMR 1058), Montpellier, France/University of Bergen, Norway/ Centre Hospitalier Universitaire de Nantes, France/ Institut de Recherche pour le Développement (IRD), France/ Mbarara University of Science and Technology, Uganda
