The role of COL11A1 in hip dysplasia and secondary osteoarthritis
Our multidisciplinary research group aims to investigate pediatric hip disorders through multiple approaches. That is why our research includes genetic epidemiology with the purpose of unravelling why some individuals are prone to getting these disorders. Recently, we published a large genome-wide association study (GWAS) on hip dysplasia, implicating a collagen gene in the development of hip dysplasia and secondary osteoarthritis. In addition, one of our researchers got the opportunity to discuss the paper in an episode of the podcast "Straight from the Hip".
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In this study, we collaborated with the All-In-Pain group from the HUNT study to examine genetic variants in relation to hip dysplasia and secondary ostearthrits. Using the available information in one of Norway's largest cohort study, we found that genetic variants close to COL11A1 altered the risk of hip dysplasia and/or secondary osteoarthritis.
After the publication of the paper, the first author Kaya K. Jacobsen had the pleasure of talking to dr. Pablo Castañeda on his podcast "Straight from the Hip". His podcast, supported by the International Hip Dysplasia Institue, features researchers from across the globe. Each episode gives insight into various aspects of the current research on hip dysplasia.
Link to the paper on COL11A1 Link to the podcast episode on the paper