Prof. Frank Conlon, University of North Carolina, USA.
Prof. Frank Conlon, from the University of North Carolina, will present: "Mechanisms of cardiac sex differences"
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Our laboratory is dedicated to researching the molecular pathways that are critical in the early development of the heart and exploring how these pathways differ between males and females, leading to disparities in heart disease. We use a comprehensive series of approaches that incorporates a broad array of techniques including developmental, genetic, proteomic, biochemical, and molecular methods. Our previous research has shown that the gene and protein networks that contribute to cardiac sex differences are influenced by both hormonal and non-hormonal factors. We have shown that the non-hormonal pathways are initiated by genes on the X-chromosome and are propagated and maintained by post-transcriptional processes. Our ultimate goal is to uncover these pathways and establish the molecular foundations that underlie sex disparities in heart disease. By understanding the genetic mechanisms behind these differences, we hope to inform and guide clinical care and treatment strategies for cardiac disease.
