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Brenk lab

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Professor Ruth Brenk

The overall research goal of the Brenk lab is to improve methods used for structure-based drug design and to apply these methods to design inhibitors for enzymes with biological relevance. A key point in our research is the interplay of theoretical and experimental methods.

For more details, check out our research page.

Paper published
Fragment hits binding to FabF

Fragment screening by X-ray crystallography

This is the newest part of our journey to design FabF inhibitors with the goal to develop new antibiotics. Here, we have used X-ray crystallography to discover hit compounds which subsequently were optimized using analogue searching, chemical space searching and manual design.

Target-RNA
TargetRNA logo

Funding for interdisciplinary MSCA doctoral training network about targeting RNA with small molecules

TargetRNA is an EU Horizon funded Marie Skłodowska-Curie Action (MSCA) doctoral training network. In this network, 16 PhD students will be trained in RNA-ligand design in the context of antimicrobial drug discovery.

Themed collecction
An RNA-ligand complex

Interested in RNA-ligand design?

Check out a themed collection about RNA-ligand design in RSC Med. Chem.

Use cases for the EU-OS fragment screening library
TOC figure, RSC Med Chem

Design, Quality and Validation of the EU-OPENSCREEN Fragment Library Poised to a High-Throughput Screening Collection

The Brenk lab has co-authored a paper describing the EU-Openscreen fragment library.

Drug discovery meeting
Ludvik Espeland presenting at the drug disocvery meeting.

Drug Discovery get together

In March, we had a Drug Discovery meeting to showcase the research that is going on Bergen and to connect the groups active in this area. Nearly 50 people had signed up of the meeting and we had 9 different talks covering topics from target discovery all the way to clinical trials.

We offer topics for the degree MSc in the area of structure-based drug design, e.g. molecular modelling, fragment screening and X-ray crystallography. Don't hestitate to contact us for chat to discuss what exactly we can offer and how we can tailor this to match your  interests.

The Brenk Lab is part of the Research Unit Structural biology and drug discovery.