Projects

Misfolding diseases

Numerous severe human diseases are caused by protein mutations as a result of inherited gene variations rendering proteins prone to misfolding. Phenylketonuria represents a paradigm of such diseases. It is related to mental retardation if left untreated, and is caused by mutations in the enzyme...

Tyrosine hydroxylase

Tyrosine hydroxylase (TH) is a tetrahydrobiopterin (BH4) dependent enzyme that catalyzes the rate limiting step in the synthesis of catecholamine neurotransmitters and hormones and is a marker for dopaminergic neurons. The research interests of our group include investigation of structural...

Membrane interactions

Biological membranes enclose both the cell and its different compartments. An essential feature of a biomembrane is that it is a selectively permeable structure. This means that the cell membrane essentially controls which molecules are allowed to interact with intracellular macromolecules. The...