News archive for Neurotargeting Research Group

Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans, linked to mutations in dozens of different genes. Two of these genes encode the proteins GDAP1 and NDRG1. We have solved the crystal structures of these two proteins, in order to better understand their structure, function, and involvement in disease.

An important European-funded initiative has been launched to explore how common molecular mechanisms may link metabolic disorders, especially type 2 diabetes and obesity, with brain disorders such as Alzheimer's disease, obsessive-compulsive disorder, and autism spectrum disorders. Jan Haavik and Aurora Martinez from the Department of Biomedicine are the norwegian participants.

Kandidaten vil holde prøveforelsning og forsvare avhandlingen: “The Characterization of Disordered Membrane-Binding Proteins of Myelin: A Biophysical Approach"

Attention-deficit/hyperactivity disorder and autoimmune diseases: etiological relationships and therapeutic possibilities

Arc er et protein som er gjerne omtalt som hukommelsens hovedregulator. Det har likhet med noen virusproteiner, og kan danne virus-lignende capsid partikkler. Vi har lykket til å oppløse den tredimensjonale strukturen for første gang.

Professor Jan Haavik, head of the Neurotargeting Research Group and KG Jebsen Center for Research on Neuropsychiatric Disorders, was recently elected as a member of the Norwegian Academy of Sciences and Letters.

The molecular processes of myelin maturation are to a large extent still unknown. A coordinated interplay between regulatory and functional molecules must take place for correct timing of myelin membrane apposition and compaction, such that cytoplasmic channels are also formed in a correct way.