Hu

Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Sensory and autonomic neuropathy
- Cerebellar ataxia
- Encephalomyelitis
- Limbic encephalitis

Most frequently associated tumors:
- Small-cell lung cancer
- Non-small-cell lung cancer
- Extrapulmonary small-cell cancer

HuD or ELAV-like protein 4 is an RNA-binding protein only present in the nuclei of neurons. HuD binds to U-rich sequences in the 3_UTRs of several mRNAs including c-fos, tau, p21waf1, N-myc, and GAP-43 to control stability and expression of these mRNAs. It is thought to be important for neuronal development and in some cases for plasticity in the mature brain.