CV2

Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Sensory and sensorimotor neuropathy
- Encephalomyelitis
- Cerebellar ataxia
- Limbic encephalitis
- Autonomic neuropathy
- Chorea

Most frequently associated tumors:
- Small-cell lung cancer
- Thymom

CV2/CRMP5 = collapsing response mediator protein 5 belongs to the family of cytosolic Ulip/CRMP proteins involved in axon guidance and neurite outgrowth signaling during neural development. CRMP5 is present in the inner mitochondrial membrane and plays an important role in mitophagy. CRMP5 can be found in the cytoplasm of oligodendrocytes.