Amphiphysin
Main content
Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Stiff-person-syndrome
- Various symptoms
Most frequently associated tumors:
- Breast cancer
- Small-cell lung cancer
Amphiphysin belongs to the superfamily of Bin–Amphiphysin–Rvs (BAR) domain proteins, which are membrane shapers and related to clathrin-mediated endocytosis because they provide extended membrane-binding interface to modulate membrane topologies. Neurons using the BAR domain superfamily members to perform synaptic formation and postsynaptic reorganization processes including receptor endocytosis and recycling as well as the structural (re)organization of synapses. [PMID:26285709; DOI: 10.1242/jcs.174193]. In the cerebellum, amphiphysin is found in presynaptic nerve terminals of the granule as well as molecular cell layer.
