SOX1

Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Lambert Eaton Myasthenia gravis

Most frequently associated tumors:
- Small-cell lung cancer

SOX1 = SRY-related high mobility group box 1 is neuronal stem cell marker and an intracellular transcription factor expressed in Bergman glia cells of the adult cerebellum. Anti-SOX1 reactivity is often associated with either Hu, VGCC, CV2/CRMP5 and amphiphysin antibodies.