Zic4

Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Cerebellar degeneration

Most frequently associated tumors:
- Small-cell lung cancer

Zic 4 = zinc-finger protein 4 of the cerebellum belongs to the family of five Zic genes, each encoding a highly related zinc-finger transcription factor. Zic4 is restricted expressed in the granule cell neurons of the cerebellum and interacts with Gli proteins to regulate Shh signaling an important factor for neuronal development and function.