Neuroprotective compounds

As current immunomodulatory therapies for Yo antibody-mediated PCD are not very effective, additional therapeutic strategies addressing in particular the Purkinje neurone degeneration are important forfuture PCD therapy. Our recent findings demonstrate that using compounds such as cyclosporin-A (CsA), cannabidiol (CBD) and butylated hydroxytoluene (BHT) that addressing calcium homeostasis imbalanceand ROS over-production seems to provide a high neuroprotective potential for Purkinje neurons ex vivo (doi: 10.1111/nan.12492).