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Translational Protein Research

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The eukaryotic NAT-machinery

Protein N-terminal acetylation

From molecular mechanisms to human disease

Most proteins are chemically modified in the cell and such modifications are often crucial for the protein’s ability to carry out a function. N-terminal acetylation one of the most common modifications in eukaryotes. It is catalyzed by N-terminal acetyltransferases (NATs) which are linked to cancer, genetic syndromes, and regulation of human metabolism.

Translational Protein Research group (Arnesen lab) is part of the Systems Biology and Translational Cell Signaling research unit at the Department of biomedicine.

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Bildet viser en CT scan av en person med hjerneforkalkning

Shedding new light on brain calcification

Brain calcification can cause movement disorders and cognitive impairment. New research by the Arnesen Lab at UiB provides increased insight into how these calcifications occur.

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UiB researchers solve protein mystery

Researchers from the University of Bergen (UiB) have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

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Bilde som er som en mini vitenskapelig poster med masse tegninger, piler og figurer

A step towards personalized diabetes treatment

Research at UiB and Haukeland gives insight into a particular form of diabetes that can be treated with alternative drugs.

New research
Impact of N-terminal acetylation in yeast

Removing protein N-terminal acetylation increases the turnover of ribosomal proteins

The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. A new UiB article adds a piece to this puzzle.

New research
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New gene variants linked to congenital heart disease

Around 600 children are born with congenital heart disease in Norway each year. Little is known about the causes of congenital heart defects. A new international study involving researchers from University of Bergen and Haukeland University Hospital shows that the NAA15 protein can play an important...