The Bergen Research Group for UltraSound in GastroEnterology (BRUSE) is world-renown for its research and novel clinical applications in the field of GI transabdominal and endoscopic ultrasonography. For over 45 years doctors at Haukeland University Hospital and University of Bergen have utilized ultrasound in clinical practice to improve management of patients with digestive diseases. A wide range of methodology has been developed and validated by BRUSE researchers, such as endosonography, three-dimensional ultrasound, hydrosonography, strain rate imaging, contrast-enhanced ultrasound, sonoelastography, advanced visualization, and several novel techniques in GI motility. Particularly, in the field of GI motility, our methods have obtained international reputation as highly original and innovative and are now used world-wide.