A woman's reproductive experience: Long-term implications for chronic disease and death

Although preeclampsia, preterm birth and other pregnancy complications can affect maternal health, this connection has not yet been studied in depth. The EU-funded HealthierWomen project aims to study the various patterns of pregnancy complications that occur alone or in combination across pregnancies and analyse their association with cause-specific maternal mortality. The research will be conducted by linking significant data from women's reproductive histories as registered at the Medical Birth Registry of Norway to population-based death and cancer registries. In this way, HealthierWomen aspires to shed light on how pregnancy complications affect long-term maternal health and to contribute to the development of more effective chronic disease prevention strategies.

Pregnancy complications such as preeclampsia and preterm birth are known to affect infant health, but their influence on mothers’ long-term health is not well understood. Most previous studies are seriously limited by their reliance on information from the first pregnancy. Often they lack the data to study women’s complete reproductive histories. Without a complete reproductive history, the relationship between pregnancy complications and women’s long-term health cannot be reliably studied. The Medical Birth Registry of Norway, covering all births from 1967-, includes information on more than 3 million births and 1.5 million sibships. Linking this to population based death and cancer registries provides a worldwide unique source of population-based data which can be analysed to identify heterogeneities in risk by lifetime parity and the cumulative experience of pregnancy complications. Having worked in this field of research for many years, I see many erroneous conclusions in studies based on insufficient data. For instance, both after preeclampsia and after a stillbirth, the high risk of heart disease observed in one-child mothers is strongly attenuated in women with subsequent pregnancies. I will study different patterns of pregnancy complications that occur alone or in combination across pregnancies, and analyse their associations with cause specific maternal mortality. Using this unique methodology, I will challenge the idea that placental dysfunction is the origin of preeclampsia and test the hypothesis that pregnancy complications may cause direct long-term effects on maternal health. The findings of this research have the potential to advance our understanding of how pregnancy complications affect the long-term maternal health and help to develop more effective chronic disease prevention strategies.

Basnet, Prativa; Skjaerven, Rolv; Harmon, Quaker E.; Sørbye, Linn Marie; Morken, Nils-Halvdan; Singh, Aditi; Klungsøyr, Kari; Kvalvik, Liv Grimstvedt.
Risk of adverse pregnancy outcomes in twin- and singleton-born women: An inter-generational cohort study. BJOG: An International Journal of Obstetrics and Gynaecology 2023 s. -
UiB FHI HVL OUS HAUKELAND

Basnet, Prativa; Skjaerven, Rolv; Harmon, Quaker E.; Wilcox, Allen J.; Klungsøyr, Kari; Sørbye, Linn Marie; Morken, Nils-Halvdan; Kvalvik, Liv Grimstvedt.
Birthweight of the subsequent singleton pregnancy following a first twin or singleton pregnancy. Acta Obstetricia et Gynecologica Scandinavica 2023 ;Volum 102.(12) s. 1674-1681
UiB FHI HVL OUS HAUKELAND

Seid, Abdu Kedir; Morken, Nils-Halvdan; Klungsøyr, Kari; Kvalvik, Liv Grimstvedt; Sørbye, Linn Marie; Vatten, Lars Johan; Skjaerven, Rolv.
Pregnancy complications in last pregnancy and mothers’ long-term cardiovascular mortality: does the relation differ from that of complications in first pregnancy? A population-based study. BMC Women's Health 2023 ;Volum 23.(1) s. -
UiB HAUKELAND FHI OUS NTNU

Sima, Yeneabeba Tilahun; Magnus, Maria Christine; Kvalvik, Liv Grimstvedt; Morken, Nils-Halvdan; Klungsøyr, Kari; Skjaerven, Rolv; Sørbye, Linn Marie.
The relationship between cesarean delivery and fecundability: a population-based cohort study. American Journal of Obstetrics and Gynecology 2023 s. 1-21
FHI HVL OUS HAUKELAND UiB

Sima, Yeneabeba Tilahun; Skjaerven, Rolv; Kvalvik, Liv Grimstvedt; Morken, Nils-Halvdan; Klungsøyr, Kari; Mannseth, Janne; Sørbye, Linn Marie.
Birth Weight in Consecutive Pregnancies and Maternal Cardiovascular Disease Mortality Among Spontaneous and Iatrogenic Term Births: A Population-Based Cohort Study. American Journal of Epidemiology 2023 ;Volum 192.(8) s. 1326-1334
UiB FHI HAUKELAND OUS

Basnet, Prativa; Skjaerven, Rolv; Sørbye, Linn Marie; Morken, Nils-Halvdan; Klungsøyr, Kari; Singh, Aditi; Mannseth, Janne; Harmon, Quaker E.; Kvalvik, Liv Grimstvedt.
Long-term cardiovascular mortality in women with twin pregnancies by lifetime reproductive history. Paediatric and Perinatal Epidemiology 2022 s. 1-9
UiB FHI OUS HAUKELAND

Sima Yeneabeba; Skjaerven, Rolv; Kvalvik, Liv Grimstvedt; Morken, Nils-Halvdan; Klungsøyr, Kari; Sørbye, Linn Marie.
Cesarean delivery in Norwegian nulliparous women with singleton cephalic term births, 1967–2020: a population-based study. BMC Pregnancy and Childbirth 2022 ;Volum 22. s. -
UiB OUS

Sørbye, Linn Marie; Cnattingius, Sven; Skjærven, Rolv; Klungsøyr, Kari; Wikström, Anna-Karin; Kvalvik, Liv Grimstvedt; Morken, Nils-Halvdan.
Interpregnancy weight change and recurrence of gestational diabetes mellitus: a population-based cohort study. BJOG: An International Journal of Obstetrics and Gynaecology 2020 ;Volum 127.(13) s. 1608-1616
UiB FHI HAUKELAND OUS

Kvalvik, Liv Grimstvedt; Wilcox, Allen James; Skjærven, Rolv; Østbye, Truls; Harmon, Quaker E.
Term complications and subsequent risk of preterm birth: registry based study. The BMJ 2020 ;Volum 369. s. -
FHI UiB