Tumour heterogeneity

Breast cancer (like most solid tumours) are heterogeneous. This means that every tumour consists of several subclones which are genetically different due to alterations arising during the evolution of the disease.

In collaboration with the Sanger Institute, we have performed multiple studies mapping the heterogeneity in early-stage (primary) breast tumours and the evolution of subclones, over time, towards a more advanced stage of the disease where the cancer has spread to other organs.

Key publications: 

• Venizelos et al Genome Medicine, 2022
• Yates et al Cancer Cell, 2017
• Yates et al Nature Med., 2015

Photo:

Mohn kreftforskningslaboratorium