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TargetRNA

Doctoral candidates

The MSCA doctoral network TargetRNA will train a cohort of 16 doctoral candidates (DCs) in an intersectoral, international and interdisciplinary setting with the aim to advance the field of RNA-ligand design. Deadline for the positions, 15. september!

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"The MSCA Doctoral Networks aim to train creative, entrepreneurial, innovative and resilient doctoral candidates, able to face current and future challenges and to convert knowledge and ideas into products and services for economic and social benefit. The MSCA Doctoral Networks raise the attractiveness and excellence of doctoral training in Europe"

Overview of the doctoral projects - click to read more!

HostProject title
AZDC 1: AI-guided design of preQ1-II and SAM-III riboswitch ligands
(WP2)
DTUDC 2: Fragment-based ligand discovery for the preQ1-II and SAM-III riboswitches
(WP2)
DTUDC 3: Discovery of recruiters of bacterial endoribonucleases
(WP2, 3)
DTUDC 4: Hit discovery and structural studies of riboswitch-ligand complexes using NMR and X-ray crystallography (WP1 and 2)
GUFDC 5: Targeting RNA to reshape the gut microbiome
(WP3)
GUFDC 6: Characterization of riboswitch-ligand interactions using NMR spectroscopy and other biophysical methods (WP1, 2 and 3)
IITDC 7: Design and synthesis of compounds targeting the group II intron of Enterobacteriales and Candida (WP2)
MUASDC 8: Mode of action studies
(WP3)
RUDC 9: Methods to study ligand-RNA target engagement in cellulo
(WP3)
UBDC 10: Lead finding and structural characterization of the 5’-UTR of ompA of A. baumannii using fragment screening and application of paramagnetic NMR restraints (WP1 and 2)
UniCADC 11: Design, synthesis and biological evaluation of RNA ligands targeting the SAM-I/IV riboswitch (WP2, 3)
UiBDC 12: Characterization of RNA-ligand interactions using X-ray crystallography and other biophysical methods (WP1, 2 and 3)
UiBDC 13: Virtual screening and design of riboswitch ligands
(WP2)
UiBDC 14: Design and synthesis of ligands for the FMN riboswitch and the 5’-UTR of ompA (WP2)
UiBDC 15: Establishing a toolbox of warheads for covalent targeting of RNA
(WP2)
UUDC 16: Structural characterization of group II introns from Enterobacterales and Candida species and the 5’UTR of ompA bound to inhibitors using cryo-EM
(WP1, 3)

Please follow the instructions "How to apply".