DC 2: Fragment-based ligand discovery for the preQ1-II and SAM-III riboswitches
Research field: Fragment-based ligand discovery, organic chemistry.
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PhD project description:
This PhD project will focus on the identification of small molecules capable of binding to and inhibiting two bacterial riboswitches, preQ1-II and SAM-III. The workflow will consist of NMR screening, hit validation, fragment-to-lead chemistry, and functional validation of lead candidates. The PhD student will work in an interdisciplinary environment where synthetic and medicinal chemistry, cell biology, and animal studies are used for chemical biology and early drug discovery projects. You will have opportunities to work with other scientists within and outside the TargetRNA doctoral network and to collaborate with and supervise undergraduate students.
Supervisor: Prof. Mads H. Clausen
Host institute: Department of Chemistry, Technical University of Denmark, Denmark
Secondments planned: Saverna Therapeutics AG, Switzerland.
Doctoral program: Chemistry at the Technical University of Denmark (https://www.kemi.dtu.dk/english/education/phdstudy)
