DC 3: Discovery of recruiters of bacterial endoribonucleases

PhD project description:

This PhD project will focus on the identification of small molecules capable of recruiting and activating bacterial endoribonucleases. The training will include protein expression, assay development, high-throughput screening, as well as chemical synthesis of putative RNA degraders. The PhD student will work in an interdisciplinary environment where synthetic and medicinal chemistry, cell biology, and animal studies are used for chemical biology and early drug discovery projects. You will have opportunities to work with other scientists within and outside the TargetRNA doctoral network and to collaborate with and supervise undergraduate students.