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News archive for The Department of Biomedicine

Impact of N-terminal acetylation in yeast
Removing protein N-terminal acetylation increases the turnover of ribosomal proteins (08.08.2023)
The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. A new UiB article adds a piece to this puzzle.
Ribotacs
Funding for work on Ribotacs (31.07.2023)
As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We look forward to a succesfull collaboration.
Dr. Stanley Makumire in the lab
Welcome to the group, Stanley! (24.07.2023)
This month, Dr. Stanley Makumire joined our group as a post-doctoral fellow. We look forward to working together in the coming years!
Ludvik Espeland presenting at the drug disocvery meeting.
Drug Discovery get together (30.03.2023)
In March, we had a Drug Discovery meeting to showcase the research that is going on Bergen and to connect the groups active in this area. Nearly 50 people had signed up of the meeting and we had 9 different talks covering topics from target discovery all the way to clinical trials.
JAES logo
Sizeable funding for our work (27.03.2023)
The second excellent news of the day was that Jane and Aatos Erkko foundation in Finland has decided to support our work with a whole 842000 € in the next three years. This decision could not have been more welcome and secures the continuation of our work. I am utmost grateful to Jane and Aatos Erkko foundation and extremely relieved. I hope one day also Norwegian funding bodies will see some... Read more
Paper title page
Henni's paper accepted in PLoS Biology (27.03.2023)
Today brought some pretty awesome news. The first came in the wee hours, telling that Henni's collaborative paper with Maddy Dans from the lab of Paul Gilson from the Burnet Institute (and a number of other collaborators) was accepted for publication in PLoS Biology. Looking forward to see this great story on inhibitors of the malaria profilactin complex finally out soon! Many thanks and huge... Read more
foundations' logos
Continued support from Meltzer foundation and UiB General Medical Fund (15.03.2023)
Last week, we got two small positive funding decisions, as we got consumable and travel money both from the Meltzer Foundation (100000 NOK) and the UiB General Medical Fund (76720 NOK). Many thanks for both foundations for continuing to support our work!
Actin II structure
Paper on Plasmodium actin II accepted for publication (03.02.2023)
Andrea's paper on the structure and cellular localization of malaria parasite actin II was accepted for publication in PLoS Pathogens today! The work was a huge long-term collaborative effort between our lab and the lab of Inga Sidén-Kiamos at IMBB-FORTH, Heraklion, Crete, and that of Peter Rosenthal at the Francis Crick Institute, London, UK.
Illustration of cell division
Darwin Day/Horizons lecture: Making Sense of Cancer (24.01.2023)
Nothing in biology makes sense except in the light of evolution. So what is the evolutionary meaning of cancer? What will it take to get rid of it? In this lecture, professor in medicine Jarle Breivik explores the evolutionary logic of cancer.
Defining substrates of the yeast NatC N-terminal acetyltransferase
Budding yeast and proteomics defined protein N-terminal acetylation (22.12.2022)
Budding yeast is a useful model system in molecular biology. Here, researchers in Bergen and Ghent used it to define one of the most abundant protein modifications in eukaryotes: N-terminal acetylation.
RSC logo
Chemical Science Reviewer Spotlight (21.12.2022)
Reviewers of the month, Dec 2022
GAC structure
Surprising structure of Toxoplasma gondii GAC (11.12.2022)
After years of work, we finally can see what the apicomplexan glideosome-associated connector (GAC) really looks like! Check out our latest preprint presenting the structure in two drastically different conformations. Based on its structure, we suggest a role for GAC as an elastic spring helping parasite motility and invasion.
Towards the discovery of new antibiotics in the lab (05.12.2022)
Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.
preprint ad
Check out our latest work on actin II (24.11.2022)
Andrea's work together with collaborators from IMBB-FORTH (Heraklion, Crete) and Francis Crick Institute (London, UK) on malaria parasite actin II is out in preprint form.
group picture
Post-doctoral (or graduate student) position in structural biology of parasite motility (23.10.2022)
We are looking for a post-doctoral fellow for a 2.5-year project (possible extension for up to 1 year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland. Alternatively, an exceptionally highly-qualified PhD student could be considered. The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. To... Read more
bioRxiv title page
Check out our latest preprint on targeting malaria parasite profilactin with drugs (22.10.2022)
Henni's recent work on characterizing compounds interfering with the malaria parasite profilin-actin complex and actin dynamics is out as a preprint on bioRxiv. The project is part of a large collaboration led by Madeline Dans and Paul Gilson from the Burnet Institute, Melbourne, Australia.
Title of the paper
Paper on MyoB accepted for publication! (14.10.2022)
Our manuscript on the smallest malaria parasite myosin, MyoB, was accepted for publication in the Journal of Biological Chemistry. Read here a summary of Isa's nice work on this so-far uncharacterized myosin, which is important for the parasite invasion of red blood cells.
Atta with opponent and custos
Atta defended his PhD thesis! (10.10.2022)
On Thursday October 6th, Atta defended his PhD thesis entitled "Structural characterization of Toxoplasma gondii armadillo repeat only protein and purification of actins from apicomplexan parasites". As the opponent, we had the pleasure of hosting Dr. Young-Hwa Song from the University of Lübeck, Germany. Huge congratulations to Atta and many thanks to the opponent and everyone who participated... Read more

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